Phosphatidylinositol turnover of cancer cell menbrane and development of new treatment of renal cell carcinoma

本文研究了癌细胞膜的特性，特别是肾癌细胞的磷脂酰肌醇(PI)代谢。我们发现，癌细胞的磷酸化和PI代谢显著增强，在一些肾癌细胞中发现~(32)&gt；P与CDP-二酰甘油(CDP-DG)的异常结合。此外，只有这些CDP-DG聚集的细胞显示c-myc基因在受试细胞中的表达增加。结果支持PI周期可能与c-myc基因表达激活有关的观点。研究了大豆等不同物种PI脂质体对人肾癌细胞的细胞毒作用。大豆PI脂质体对PI代谢增强的肾癌细胞具有特异性杀伤作用。我们认为不同品种的PI脂质体可能是治疗肾癌的一种有用的新方法。

Characteristics of cancer cell menbrane, espicially phosphatidyl-inositol (PI) metabolism of renal cancer cells, were investigated. AND a new approach for treatment of renal cancer depending on these charactristics were preliminary studied.We found, phosphrylation and PI metabolism were greatly enhanced in cancer cells and, exceptional incorperation of ^<32>P into CDP-diacylglycerol (CDP-DG) was found in some of renal cancer cells.Furthermore, only these CDP-DG accumulated cells showed an increased c-myc gene expression among the cells tested. The results support the idea that PI cycle might be associated with the activation of c-myc gene expression.Cytotoxic effects of liposomes of PI from different species like soybean , on human renal cancer cells were studied. Soybean PI liposome specifically killed the renal cancer cells whose PI metabolism were enhanced. And we concluded that PI liposome from different species could be one of the useful new modality for the treatment of renal cancer.