Totally implantable artificial heart & its hemocompatibility

讨论了目前全植入型全人工心脏发展中存在的问题，特别是抗血栓形成方面的问题。在国家心血管中心，电液型全人工心脏正在研制中。该系统的优点是可以分别植入两个脑室。然而，电机反向旋转的能量损失是该系统中需要解决的问题。为了促进泵的抗血栓性能，一种基于表面光反应化学的新型表面处理技术也在开发中。在东京大学，一种独特的全人工心脏正在研发中。该系统由一个离心泵(CFP)和两个三通阀组成。每个三通阀的一个端口分别连接到CFP的入口和出口。每个瓣膜的另外两个端口分别与右、左心房、肺动脉和主动脉相连。通过切换两个三通瓣，CFP可以交替地以脉动流的方式对肺和体循环进行灌流。CFP中的血液混合物和抗血栓形成是这个系统中的问题。在首尔国立大学，一种移动致动器类型的全人工心脏正在研发中。动物在该系统下存活了100小时。人们正在研究用内皮细胞和蛋白水解酶对聚合物表面进行修饰以促进抗血栓形成。

Present problems in the development of totally implantable total artificial heart were discussed especially focusing on the antithrombogenesity. In the national cardiovascular center, electrohydraulic type total artificial heart is under development. The merit of this system is that both ventricles can be separately implanted. However, energy loss to reverse the motor rotation is a problem to be solved in this system. To promote the antithrombogenesity of the pump, a novel surface process technology based on surface photoreactive chemistry is also under development. In the university of Tokyo, a unique total artificial heart is under development. This system is composed of a single centrifugal pump (CFP) and two three-way valves. One port of each three-way valve is connected to the inlet and outlet of a CFP, respectively. The other two ports of each valve are connected to the right and left atrium, p ulmonary artery and aorta. The CFP can perfuse the pulmonary and systemic circulation alternately with pulsatile flow by switching the two three-way valves. Blood mixture in the CFP and antithrombogenesity are problems in this system. In Seoul national university, a moving-actuator type total artificial heart is under development. Animal survived for 100 hours with this system. Polymer surface modification with endothelial cells and proteolytic enzyme is being examined to promote antithrombogenesity.