Placental function and development of fetal nervous system.

胎盘具有多种功能，包括母婴之间的营养物质和废物运输，调节母婴免疫系统以防止相互排斥，以及维持妊娠的内分泌功能，在胎儿的生长和生存、维持妊娠期间母体代谢状态等方面发挥着重要作用。胎盘的主要内分泌参与归因于胎盘乳原（PLs）。考虑到大鼠在泌乳素开始分泌后每日两次的泌乳素高峰停止的现象，以及与泌乳素结构相关的泌乳素对动物母性行为的刺激，提出了泌乳素对母性神经功能的影响。在本研究中，我们发现了PL或催乳素受体mRNA在胎儿发育过程中在胎鼠大脑中表达。我们还成功地分离了一种新的PL- im的cdna克隆，并产生了重组蛋白。在这些研究过程中，获得了在发育中的胎儿大脑中识别分子的单克隆抗体。20 α -羟基类固醇脱氢酶mRNA在胎盘中表达以保护胎儿免受母体类固醇环境的影响。

The placenta plays an essential role in fetal growth and survival, maintenance of the maternal metabolic status during pregnancy by virtue of its multiple functions relating to the transport of nutrients and waste between mother and fetus, modulation of the maternal and fetal immune systems to prevent rejection of each other, and its endocrinological function of maintaining the pregnancy. The main endocrine participation of the placenta is attributed to placental lactogens(PLs). Considering the phenomenon that twice daily surges of prolactin ceased when secretion of PLs started in the rat and administration of prolactin, which is structurally related to the PLs, stimulates maternal behavior the animals, the PLs are proposed to affect the central nervous function in the dam. In the present study, we showed that the mRNA for PL or prolactin receptor expressed in the fetal rat brain during fetal development. We also succeeded to isolate cDNAclone for a novel PL,PL-Im, and produce the recombinant protein. In the course of these studies, monoclonal antibodies which recognize the molecule in the developing fetal brain were obtained. mRNA for 20alpha-hydroxysteroid dehydrogenase expressed in the placenta to protect the fetus from the maternal steroid environment.