Joint Study to Develop a Long-term Use Artificial Heart

随着人工心脏在短期临床应用中的成功，迫切需要人工心脏作为心脏移植的桥梁进行更长期的应用。本联合研究的目的是东京大学、东北大学、国立心血管中心和维也纳大学在人工心脏和生物材料开发方面的长期经验的基础上，进行以下项目的合作研究：1）明确人工心脏临床使用过程中的问题。2)目的：研制一种安全可靠、可长期应用于临床的人工心脏系统。本年度取得了以下成果：1维也纳大学的一名合作成员应邀到东京大学讨论上述项目; 2七名日本成员访问维也纳大学，讨论人工心脏的临床应用; 3通过这些交流，进行了以下讨论：（1）人工心脏、解剖学、生物医学、 ...更多信息 东京大学正在开发的全人工心脏和辅助循环的临床拟合和血液相容性，（2）水母瓣上产生钙化的原因及其对策，（3）东京大学正在实施的全人工心脏的1/R控制方法的适当性及其临床应用的可能性，（4）东北大学开发的振动流泵左心转流过程中频率与血流分布的关系及混沌理论评价血流动力学的适宜性，（5）维也纳大学开发的离心泵性能和血液相容性的改进，（6）血液动力学数据、血液化学数据、控制方法，抗凝治疗和并发症的临床患者植入心室辅助装置的桥梁心脏移植，（七）通过国家心血管中心开发的材料和方法改善人工心脏的血液相容性。4这些结果在第42届会议上报道。美国人工器官学会年会、第六届人工心脏和辅助装置国际研讨会、第23届欧洲人工器官学会大会和第34届日本人工器官学会年会。少

As the consequence of the success in short-term clinical use of artificial heart, longer term application of artificial heart for the bridge to heart transplantationis strongly required. This joint study was designed to perform cooperative research of the following items among University of Tokyo, Tohoku University, National Cardiovascular Center and Wien University under their longterm experiences to develop the artificial heart and biomaterials : 1) To clarify the problems during clinical use of artificial heart. 2) To develop a safer and more reliable artificial heart system that can be used clinically for longterm. The following outoutcome have been obtained in this year.1 A cooperative member in Wien University was invited to University of Tokyo to discussed above mentioned items.2 Seven Japanese members visited to Wien University to discuss about the clinical use of artificial heart.3 The following discussions have been done through these interchanges : (1) the peformance, anatom … More ical fitting and blood compatibility of total artificial heart and assist circulation that are developing in University of Tokyo, (2) the cause of calcification generated on the jellyfish valve and measures for it, (3) appropriateness of 1/R controlmethod of total artificial heart that have been performing at University of Tokyo and its possibility to apply clinically, (4) the relationship between frequency and blood distribution during the left heart bypass with vibrating flow pump developed by Tohoku University and appropriate ness of hemodynamics evaluation with chaos theory, (5) the improvement of the performance and blood compatibility of the centrifugal pump developed by Wien University, (6) the hemodynamic data, blood chemical data, control method, anticoagulant therapy and complications of clinical patients implanted a ventricular assist device for bridge to heart transplantation, (7) improvement of blood compatibility og an artificial heart by the materials and methods developed at National Cardiovascular Center.4 These reurlts were reported at 42nd Annual Meetings of American Society for Artificial Internal Organs, 6th International Symposium on Artificial Heart and Assist Devices, 23rd Congress of European Society for Artificial Organs and 34th Annual Meetings of Japanese Society for Artificial Organs. Less