课题基金 / 基金详情

The role of phosphoinositides in endosomal maturation dynamics.

The role of phosphoinositides in endosomal maturation dynamics.
磷酸肌醇在内体成熟动力学中的作用。
批准号:
DP220103810
负责人:
Prof Christina Mitchell
金额:
$41.77万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2022
资助国家:
澳大利亚
项目状态:
未结题
起止时间:
2022-03-01 至 2025-02-28

项目摘要

项目成果

Prof Christina Mitchell的其他基金

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中文摘要
翻译
本项目旨在研究细胞内称为核内体的细胞内腔室的调节,核内体在细胞稳态、信号传导和病原体进入中起关键作用。利用独特的多学科方法,结合最先进的成像技术和高通量蛋白质分析,预计将在理解内核体成熟和驱动这一过程的信号事件方面产生新的知识。预期的结果将是确定控制内体上指导内体成熟的膜结合机制的分子步骤。这将为描述与细胞生命的几乎所有方面相关的过程提供重要的好处。
英文摘要
This project aims to investigate the regulation of an intracellular compartment within a cell called endosomes, which plays critical roles in cellular homeostasis, signalling and pathogen entry. New knowledge is expected to be generated in understanding endosome maturation and the signalling events that drive this process using a unique, multidisciplinary approach combining state of the art imaging techniques and high throughput protein analysis. The anticipated outcomes will be to define the molecular steps that govern the membrane-bound machinery on endosomes that directs endosomal maturation. This should provide significant benefits in delineating a process that is linked to almost all aspects of cell life.
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会议论文
Phosphoinositide regulation of lysosome reformation during autophagy
  • 批准号:
    DP190102499
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $33.36万
  • 财政年份:
    2019
  • 负责人:
    Prof Christina Mitchell
  • 依托单位:
Regulation of neurite outgrowth by an inhibitor of PI3K signalling.
  • 批准号:
    DP110103655
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $29.56万
  • 财政年份:
    2011
  • 负责人:
    Prof Christina Mitchell
  • 依托单位:
Characterization of a novel regulator of angiogenesis
  • 批准号:
    nhmrc : 1010368
  • 项目类别:
    NHMRC Project Grants
  • 资助金额:
    $39.49万
  • 财政年份:
    2011
  • 负责人:
    Prof Christina Mitchell
  • 依托单位:
MTMR4, a regulator of PtdIns(3)P
  • 批准号:
    nhmrc : 545989
  • 项目类别:
    NHMRC Project Grants
  • 资助金额:
    $40.19万
  • 财政年份:
    2009
  • 负责人:
    Prof Christina Mitchell
  • 依托单位:
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