Investigating Hippo-regulated transcription at single molecule resolution

信号通路贯穿整个生命，将细胞外世界的信号传递到细胞核，控制转录并引发反应。该项目旨在了解河马生长控制途径如何调控转录。该项目结合生物学、生物物理学和计算生物学，旨在量化河马途径转录因子在亚微米分辨率下的行为，以及河马信号如何调节它们的行为、与基因组的相互作用和功能。我们预计我们的发现将促进新的研究，例如测试其他信号通路如何调节转录。预期的好处是创造就业机会和有关生活基本原则的新知识。

Signalling pathways operate throughout life to relay signals from the extracellular world to the cellular nucleus, to control transcription and elicit a response. This project aims to understand how the Hippo growth control pathway regulates transcription. Using a combination of biology, biophysics and computational biology, this project aims to quantify behaviour of the Hippo pathway transcription factors at sub-micron resolution, and how Hippo signalling modulates their behaviour, interaction with the genome and function. We anticipate our discoveries will stimulate new research, e.g. testing of how other signaling pathways regulate transcription. Intended benefits are creation of jobs and new knowledge on fundamental principles of life.