Angiogenesis in female genital tract cancers and its inhibition

以血小板衍化内皮细胞生长因子(PD-ECGF)标记的胸苷磷酸化酶(TP)在宫颈癌中的表达与微血管密度和患者预后相关。尤其是从原发肿瘤到转移淋巴结的PD-ECGF水平升高被认为是判断患者预后的更敏感的指标。此外，无论组织学类型如何，血清PD-ECGF均可作为宫颈癌进展的一种新的肿瘤标志物。宫颈癌中血管生成转录因子Ets-1与PD-ECGF和IL-8相关由于PD-EGGF和ETS-1可通过血管生成促进生长和继发扩散，因此由5-氟尿嘧啶、PD-ECGF底物和ETS-1抑制剂组成的掩蔽化合物可能对宫颈癌有效，尤其是在转移的淋巴结上。卵巢癌组织中血管内皮生长因子亚型…的表达More-65和Ets-1与患者预后相关，但与组织学类型和临床分期无关，尤其是在腹膜转移灶中。由于VEGF和ETS-1可通过血管生成促进卵巢癌的生长和继发扩散，因此，VEGF受体酪氨酸激酶抑制剂、抗VEGF抗体和ETS-1抑制剂可能对卵巢癌，特别是腹膜转移性病变有效。碱性成纤维细胞生长因子在子宫内膜癌中的表达与临床分期有关。PD-ECGF和VEGF的表达受性激素的部分调控，可能与子宫内膜癌的早期发展有关。IL-8在子宫肌层侵袭中被诱导并达到峰值，可能作为血管生成开关发挥作用。Ets-1在高分化子宫内膜癌中的表达与血管内皮生长因子的表达呈正相关，在低分化子宫内膜癌中的表达与bFGF的表达呈正相关。因此，必须针对与临床分期和分化程度相关的靶血管生成因子，抑制子宫内膜癌的特异性血管生成，从而达到高效治疗子宫内膜癌的目的。较少

In uterine cervical cancers, the expression of thymidine phosphorylase ( TP ) identified with platelefrderived endothelial cell growth factor ( PD-ECGF ) correlated with microvessel density and patient prognosis. Especially, the increased level of PD-ECGF from the primary tumor to metastatic lymph nodes was recognized as a more sensitive indicator for patient prognosis. Furthermore, serum PD-ECGF can be used a novel tumor marker for advancement of uterine cervical cancers regardless of histopathological types. The transcription factor ets-1 for angiogenesis linked to PD-ECGF and interleukin ( IL )-8 in uterine cervical cancers. As PD-EGGF and ets-1 can be considered to promote growth and secondary spreading via angiogenesis, masked compounds of 5-fluorouracil, substrates of PD-ECGF, and ets-1 inhibitors might be effective on uterine cervical cancers, especially on the metastatic lymph nodes. In ovarian cancers, the expression of vascular endothelial growth factor ( VEGF ) isoform VEGFi … More 65 and ets-1 correlated with patient prognosis, but not with histopathological types and clinical stages, especially in metastatic peritoneal lesions. As VEGF and ets-1 can be considered to promote growth and secondary spreading via angiogenesis, VEGF receptor tyrosine kinase inhibitors, anti-VEGF antibodies and ets-1 inhibitors might be effective on ovarian cancers, especially on metastatic peritoneal lesions. In uterine endometrial cancers, the expression of basic fibroblast growth factor ( bFGF ) correlated with clinical stages. The expression of PD-ECGF and VEGF was partially regulated by sex steroids, and they might grow the early stage of uterine endometrial cancers. IL-8 was induced and reached to the peak level in myometrial invasion, and might work as an angiogenic switch. The expression of ets-1 in well-differentiated uterine endometrial cancers correlated with that of VEGF, and the expression of ets-1 in poorly differentiated uterine endometrial cancers correlated with that of bFGF. Therefore, the target angiogenic factors associated with clinical stages and differentiated grades must be attacked to suppress the specific angiogenesis, which might lead to highly effective treatment with uterine endometrial cancers. Less