Immunogenetic study on Mongoloids in Asian-Pacific and Polar areas

为了从人类T细胞白血病病毒（HTLV-I）和B肝炎病毒（HBV）的独特分布中阐明亚太地区蒙古人种的免疫遗传学特征，本研究在北欧和俄罗斯西北部地区进行了国际比较研究。2003年，我们分析了挪威北部土著居民的抗HTLV-I抗体。在获得挪威当局和萨米社区的正式许可后，我们使用了800份血清样本（400名萨米人和400名非萨米人）。所有样本都是25年前出于其他目的收集的，并储存在奥斯陆大学的深冻库中。所有样本的抗HTLVI抗体均为阴性，我们得出结论，挪威北部土著萨米人不携带HTLV-I。2）2004年底，我们与阿尔汉格尔斯克大学合作，针对涅涅茨自治区Nariyan Mar的涅涅茨人开展了为期三天的实地工作。 ...更多信息 在获得每名受试者的知情同意后，从Krasnoe镇的109名受试者（中心诊所的患者和普通居民）中采集10 ml血液样本。我们在中心诊所的实验室将血沉棕黄层与血浆分离，并将其带回阿尔汉格尔斯克大学。我们分析了HTLV-Ⅰ的抗体，没有发现阳性携带者。在肝炎病毒方面，我们发现抗-HCV和抗-HBV阳性分别为3例（2.8%）和30例（28%）。在30例抗-HBV阳性者中，没有HBV抗原携带者，我们不能确认该人群中HBV的遗传亚型。从本研究包括以前在亚洲大陆进行的研究中，我们不能确认在日本列岛的日本人以外的土著蒙古人中HTLV-I携带者的聚集性。我们需要对HTLV-I进行最后的研究，以澄清蒙古人的传播，以1）确认格陵兰东北部因纽特人中的HTLV-I，2）调查安第斯山脉沙漠中埋葬的8000 -500年前的木乃伊中的HTLV-I。少

To clarify immunogenetic characteristics of Mongoloids in Asian Pacific regions from unique distribution of human T-cell leukemia virus(HTLV-I) and hepatitis B virus(HBV), the present international comparative study was conducted in the North Scandinavian and Northwestern Russian areas.1)In cooperation with epidemiologists of Osb University and Tromse University in Norway, we analyzed anti-HTLV-I antibodies of indigenous people in North Norway in 2003. We used 800 serum samples (400 Sami people and 400 non-Sami people) after getting official permission of Norway authorities and Sami community. All samples were collected 25 years ago for the other purposes and stored in the deep freezer in Oslo University. All samples were negative anti-HTLVI and we concluded that North Norway indigenous Sami people don't carry HTLV-I.2)In cooperation with Arkhangelsk University, we conducted field work targeting Nenezt people in Nariyan Mar, Nenets autonomous areas for three days in the end of 2004 We … More collected 10 ml blood samples from 109 subjects (patients of Central Clinics and general inhabitants) in Krasnoe town after getting informed consent from each subject. We separated buffy coat from plasma in the laboratory of the Central Clinics and carried back them to Arkhangelsk University. We analyzed antibodies of HTLV-I and we could not find a positive carrier. In terms of hepatitis viruses, we found 3 (2.8%) and 30 (28%) positives of anti-HCV and anti-HBVs. Among 30 anti-HBVs positives, there is no HBV antigen carrier and we could not confirm a genetic subtype of HBV in this population.From the present study including the previous studies held in Asian Continent, we could not confirm clustering of HTLV-I carriers among indigenous Mongoloids except Japanese in Japan archipelago. We need final studies on HTLV-I to clarify Mongoloids dispersal as to 1)confirmation of HTLV-I among Inuit people in the northeastern Greenland, and 2)investigation of HTLV-I among mummies 8,000-500 years old buried in Andes desert. Less