Molecular Clocks to Biological Rhythms

1997年生物钟基因的发现和随后对生物钟基因分子机制的研究，使“生物时间”成为研究对象。我们开始本研究作为一个项目的后克隆时代。我们阐明了G蛋白介导的新的细胞通讯在视交叉上核。我们人工合成了一个调控时钟基因转录的转录因子。我们还阐明了肝脏中核酸代谢的时间机制，膀胱中的有丝分裂节律，此外，我们在肾上腺中鉴定了一种新的类固醇合成酶，该酶将生物钟和高血压联系起来。

The discovery of clock genes at 1997 and the following study of the molecular machinery of clock genes, have enabled “biological time” as a research object. We begin the present study as a project of post-cloning age. We clarified the G-protein mediated novel cellular communications in the suprachiasmatic nucleus. We synthesized an artificial transcriptional factor regulating the clock gene transcriptions. We also clarified a timing mechanism of nucleic acid metabolism in the liver, miturition rhythm in the urinary bladder, and further, we identified a novel steroid synthetic enzyme, which links between circadian clock and hypertension, in the adrenal gland.