Nanoprobe and Microprobe Spectroscopic Techniques in Drug Design, Probing Mechanisms of Diseases, and Bioinorganic Chemistry
Nanoprobe and Microprobe Spectroscopic Techniques in Drug Design, Probing Mechanisms of Diseases, and Bioinorganic Chemistry
批准号:
DP0346162
负责人:
Prof Peter Lay
金额:
$19.24万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2003
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2003-03-01 至 2006-02-28
中文摘要
纳米探针和微探针光谱技术提供了无与伦比的机会来探测药物、致癌物和生物分子在培养细胞和组织中的结构和分布。这些技术代表了在分子水平上了解体内代谢过程的新领域,并提供了有关药物和毒素的代谢和分布的前所未有的信息,这些药物和毒素与癌症等疾病的治疗和病因有关。该项目旨在推动纳米探针和微探针(x射线吸收、SRIXE、PIXE、拉曼和双光子荧光)技术在这些应用中的应用。
英文摘要
Nanoprobe and microprobe spectroscopic techniques offer unparalleled opportunities to probe the structures and distributions of drugs, carcinogens, and biomolecules in cultured cells and tissues. Such techniques represent new frontiers in understanding in vivo metabolic processes at the molecular level, as well as providing unprecedented information on the metabolism and distributions of pharmaceuticals and toxins involved in the treatment and cause of diseases, such as cancer. This project is aimed at pushing the boundaries of nanoprobe and microprobe (X-ray absorption, SRIXE, PIXE, Raman and two-photon fluorescence) techniques for such applications.
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会议论文
Metal Virulence and Therapeutic Factors in Pathogen Bioinorganic Chemistry
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资助金额:$42.2万
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财政年份:2021
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依托单位:
Rapid Molecular (Bio)material Imaging by Infrared and Raman Microscopies
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批准号:LE200100043
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Bioinorganic chemistry between immune cell and pathogen
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财政年份:2018
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依托单位:
Roles of Metal Complexes in Carbohydrate Metabolism – Anti-Diabetic Drugs
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资助金额:$34.92万
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财政年份:2016
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负责人:Prof Peter Lay
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依托单位:
Pushing the Boundaries of Multi-modal Biospectroscopic Microscopies
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批准号:DP140100176
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项目类别:Discovery Projects
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资助金额:$36.31万
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财政年份:2014
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负责人:Prof Peter Lay
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依托单位:
The roles of metal complexes and related metalloproteins in the essential and therapeutic control of diabetes
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批准号:DP130103566
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项目类别:Discovery Projects
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资助金额:$31.98万
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财政年份:2013
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负责人:Prof Peter Lay
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依托单位:
Innovative synchrotron science - program for access to the Australian National Beamline Facility and cutting-edge beamlines at international synchrotrons
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批准号:LE110100174
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$53.34万
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财政年份:2011
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负责人:Prof Peter Lay
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依托单位:
Design and Mechanistic Studies of Metal-Based Anti-Diabetic Drugs
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批准号:DP1095310
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项目类别:Discovery Projects
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资助金额:$31.35万
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财政年份:2010
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负责人:Prof Peter Lay
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依托单位:
Microprobe and Nanoprobe Studies on Intracellular Disease Processes and Their Treatment
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批准号:DP0984722
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项目类别:Discovery Projects
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资助金额:$70.59万
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财政年份:2009
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负责人:Prof Peter Lay
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依托单位:
Integrated Vibrational Spectroscopic Mapping for Archeological, Biological, Geological, Materials, and Medical Research
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批准号:LE0883036
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$26.67万
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财政年份:2008
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负责人:Prof Peter Lay
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依托单位:
Biomolecular chemical survival strategies of terrestrial extremophiles and the spectroscopic search for life on Mars
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批准号:LX0776464
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项目类别:Linkage - International
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资助金额:$2.68万
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财政年份:2007
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负责人:Prof Peter Lay
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依托单位:
The roles of metal ions in glucose metabolism and the treatment of diabetes
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批准号:DP0774173
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项目类别:Discovery Projects
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资助金额:$27.35万
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财政年份:2007
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负责人:Prof Peter Lay
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依托单位:
Nanoprobe and Microprobe Structural and Spectroscopic Studies in Biomedical Research
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批准号:DP0664706
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项目类别:Discovery Projects
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资助金额:$23.68万
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财政年份:2006
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负责人:Prof Peter Lay
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依托单位:
Vibrational Spectroscopy Microprobe/FESEM/AFM Imaging of Cells, Tissues and Materials
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批准号:LE0560680
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$60.14万
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财政年份:2005
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负责人:Prof Peter Lay
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依托单位:
Metals in Medicine
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批准号:SR0354474
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项目类别:Special Research Initiatives
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资助金额:$2.0万
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财政年份:2004
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负责人:Prof Peter Lay
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依托单位:
Metal-Based Anti-inflammatory Drugs with High Efficacy and Low Side-Effects
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批准号:LP0453765
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项目类别:Linkage Projects
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资助金额:$24.47万
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财政年份:2004
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负责人:Prof Peter Lay
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依托单位:
Fluorescence Detector for the Australian National Beamline Facility
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批准号:LE0346515
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$33.81万
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财政年份:2003
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负责人:Prof Peter Lay
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依托单位:
The Chemistry and Biochemistry of Chromium: Cancer and Nutrition
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批准号:DP0208409
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项目类别:Discovery Projects
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资助金额:$70.17万
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财政年份:2002
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负责人:Prof Peter Lay
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依托单位:
海外基金