Attempts to develop a novel cell therapy system for chromic viral infections and non-viral tumors.

我们的工作是使用新开发的NOG小鼠对病毒诱导的疾病（HTLV-I/ATL、HIV-I/AIDS和EBV/AIDS相关淋巴瘤）和非病毒诱导的癌症进行形态学、遗传学和分子学研究。我们初步建立了一种新的动物模型，ATL无条件NOG小鼠。我们还展示了几种新开发的NF-κ B抑制剂的效果。我们证明了NK细胞在NOG小鼠以及乳腺癌患者中的有效性和安全性。我们还通过移植人脐带血来源的造血干细胞来构建人源化NOG小鼠，所述造血干细胞最终发育成人B细胞、T细胞和其他单核细胞/巨噬细胞以及与淋巴组织中淋巴滤泡样结构的产生相关的树突状细胞。该系统允许HIV-1和EBV的持久感染与人类免疫反应。所有这些数据表明，NOG小鼠可能有潜力作为一个有用的动物模型，用于开发新的方案，对各种传染病和人类起源的癌症。

Our efforts have been made regarding morphological, genetic and molecular studies on virally-induced diseases (HTLV-I/ATL, HIV-I/AIDS, and EBV/AIDS-associated lymphoma) and non-virally induced cancers using newly developed NOG mice. We initially established a novel animal model for ATL using unconditional NOG mice. We also showed the effect of several newly developed NF-kB inhibitors. We proved efficacy and safety of NK cells in NOG mice as well as in the breast tumor-bearing patients. We also constructed humanized NOG mice by transplanting human cord blood-derived hematopoietic stem cells that eventually developed into human B cells, T cells and other monocytes/macrophages and dendritic cells associated with the generation of lymphoid follicle-like structures in lymphoid tissues. This system allows a long-lasting infection of both HIV-1 and EBV with human immune responses. All these data suggest that NOG mice may have potential as a useful animal model for the development of new regimen against various infectious diseases and cancers of human origin.