Development of multi-functional denture liner

为了研制一种无醇型多功能义齿衬垫，制备了由脂肪族乙烯基酯（VE）液体和聚甲基丙烯酸乙酯（PEMA）粉末组成的新型义齿衬垫。对于VE，从气味的角度考虑，选择了高分子量、室温下为液体的癸二酸二乙烯酯（DVS）和癸二酸甲基乙烯酯（MVS）。通过与4种市售组织调理剂（TC）的粘弹性比较，评价了新型DL作为组织调理剂（TC）的可能性;通过与典型市售DL的弯曲性能比较，评价了聚合新型DL作为长期DL的可能性。在混合后2小时，DVS/PEMA和MVS/PEMA糊剂的初始应力松弛行为与典型商业TC相当。VE/PEMA糊剂的初始硬度也与商业TC相当。而VE/PEMA糊在分散液中浸泡后的硬度比分散液中的硬度低。水在37℃下放置2周，硬度变化幅度为-14%，而商品TC的硬度随时间的延长而增加85-269%。在28 ~ 58 MPa范围内，热聚合VE/PEMA糊的弯曲性能与商业DL的弯曲性能相似。由AVE和PEMA组成的新型DL成功地用作TC和长期硬DL，证明了这些新型材料的多用途效用。对DVS和MVS用于DL的可行性进行了雌激素活性、细胞毒性和皮肤致敏效力的检查。测试的乙烯基酯均未表现出任何雌激素活性。VE的IC 50值（抑制50%活力所需的化学浓度）大于20 mM。DVS和MVS具有一定的致敏潜力，但被认为仅具有弱的皮肤致敏效力。

To develop a multi-functional denture liner (DL) without an alcohol, the novel DLs composed of aliphatic vinyl ester (VE) liquid and poly(ethyl methacrylate) (PEMA) powder were prepared. As for VE, Divinyl sebacate (DVS) and Methyl vinyl sebacate (MVS) were selected as a high molecular weight and liquid at room temperature on the viewpoint of odor. The possibilities on mechanical properties of novel DLs were evaluated the potential as a tissue conditioner (TC) in comparison with 4 kinds of commercial TC on viscoelastic properties, and the possibilities on mechanical properties of polymerized novel DLs were evaluated the potential as a long-term DL in comparison with typical commercial DLs on the flexural properties. The initial stress relaxation behavior of DVS/PEMA and MVS/PEMA pastes were equivalent those of typical commercial TCs at 2 hrs after mixing. The initial hardness of VE/PEMA pastes were also equivalent those of commercial TC. However, the hardness of VE/PEMA pastes after immersion in dist. water at 37℃ for 2 weeks was changed only by -14% with that at the initial, while the hardness of commercial TCs increased by 85-269% with storage. The flexural properties of thermo-polymerized VE/PEMA pastes were similar to those of commercial DLs in the range of 28 to 58MPa. The novel DLs, composed of AVE and PEMA, were successfully used as both a TC and long-term hard DL, demonstrating the multiple purpose utility of these novel materials. The feasibility of DVS and MVS for DL were examined for estrogenic activity, cytotoxicity and skin sensitization potency. None of the vinyl esters tested exhibited any estrogenic activity. The IC50 values (the chemical concentration required to inhibit viability by 50%) of VE were more than 20mM. DVS and MVS have some potential to cause skin sensitization but was regarded as having only weak skin sensitizing potency.