Co-ordinated Action of ATM and DNA-PK in DNA damage recognition

本项目旨在探讨辐射损伤后DNA双链断裂的修复机制。具体来说，我们将重点关注两种蛋白ATM（在遗传性疾病共济失调-毛细血管扩张症中突变）和DNA-PK在scid小鼠中突变。有两种蛋白质识别DNA中的双株断裂，并向细胞的DNA修复机制和细胞周期检查点发出这种损伤的信号。这里的重点将是这两种蛋白质在协调DNA断裂修复中的关系。这些信息对于理解维持基因组完整性的机制非常重要。

The aim of this project is to investigate the mechanism of repair of double straind breaks in DNA sustained after radiation damage. Specifically we will focus on two proteins ATM (mutated in the genetic disorder ataxia-telangiectasia) and DNA-PK mutated in scid mice. There two proteins recognize double straind breaks in DNA and signal this damage to the DNA repair machinery of the cell and to cell cycle checkpoints. The emphasis here will be in the relationship between the two proteins in co-ordinating the repair of breaks in DNA. This information will be important in understanding mechanisms for maintaining the integrity of the genome.