Alternative Splicing in the Mouse Transcriptome

尽管人类基因组的完成令人兴奋，但我们没有任何确切的迹象表明，哺乳动物基因组中存在多少蛋白质编码基因。我们甚至没有迹象表明这些基因产生替代基因产物的程度，通过一个过程称为替代剪接。这些全长替代基因产物的检测和测序是该应用的重点。此应用程序详细说明了参与小鼠全转录组鉴定的机会，并且是与日本理化学研究所基因组科学中心合作努力的一部分。

Although the human genome completion is cause for excitement we do not have any firm indication of precisely how many protein-coding genes exist in a mammalian genome. We have even less indication of the extent to which these genes generate alternative gene products, through a process termed alternative splicing. The detection and sequencing of these full-length alternative gene products is the focus of this application. This application details the opportunity to participate in the identification of the full transcriptome of the mouse and is part of a collaborative effort with The RIKEN Genome Sciences Center in Japan.