Epidemiological research for the relationship between Helicobacter pylori infection and gastrointestinal diseases in Asia

本研究采用分子流行病学的方法对幽门螺杆菌感染的病理状态进行了分析，因为这些病理状态存在着所谓的民族之谜。结果表明，东亚型CagA阳性H.pylori感染与萎缩性胃炎的程度和胃癌的发生密切相关。未来，通过对感染东亚型CagA阳性幽门螺杆菌（被认为与萎缩性胃炎和随后的胃癌的发展密切相关）的患者进行个性化根除治疗，预计亚洲消化性溃疡和胃癌的发病率可能会降低

In this study, the pathological conditions in H.pylori infection were analyzed with the molecular epidemiological methods, because those had the problem, so called Ethnical enigma. As a result, it was revealed that the infection of East Asian type CagA positive H.pylori was closely associated with the degree of atrophic gastritis and the development of gastric cancer. In the future, by the personalized eradication therapy for the patients infected with East Asian type CagA positive H.pylori, which is considered to be associated strongly with the development of atrophic gastritis and subsequent gastric cancer, it is expected that the incidence rate of peptic ulcer and gastric cancer might be decreased in Asia