Development of cell, gene and drug delivery system to the cardiovascular tissue using a novel cell-surface lectin.

我们发现了心血管组织的波形蛋白和结蛋白的新功能，通过这些蛋白质与细胞表面上的生理GlcNAc承载配体通过其GlcNAc结合凝集素样性质相互作用。用GlcNAc包被骨髓细胞表面可促进这些细胞与心肌细胞的粘附及其向心肌细胞的再生，这将有助于骨髓移植治疗心血管疾病。

We found a novel function of vimentin and desmin of cardiovascular tissues by which these proteins interact with physiological GlcNAc-bearing ligands on the cell surface through their GlcNAc-binding lectin-like properties. Cell surface coating of bone marrow cells with GlcNAc promoted adhesion of these cells to cardiac myocytes and their regeneration to cardiac myocytes, and this would be useful for the treatment of cardiovascular disease with bone marrow implantation.