The role of endoplasmic reticulum (ER) stress in non-alcoholic steatohepatitis

内质网应激在非酒精性脂肪性肝炎中的作用尚未完全阐明。由于CHOP是内质网应激相关分子之一，我们使用蛋氨酸-胆碱（MCD）缺乏饮食，在脂肪性肝炎小鼠模型中比较CHOP敲除（KO）小鼠和野生型（WT）小鼠。与WT小鼠相比，MCD饮食1周后KO小鼠肝组织脂肪变性、中性粒细胞浸润和细胞凋亡明显减少。但这些显著的差异是短暂的。PPAR γ在KO小鼠和WT小鼠中表达至峰值的时间不同。这可能是造成KO小鼠与WT小鼠病理生理变化差异的原因之一。

The role of endoplasmic reticulum (ER) stress in nonalcoholic steatohepatitis has not been fully elucidated. Because CHOP is one of the ER stress-related molecules, we compared CHOP knock out (KO) mice and wild type (WT) mice in steatohepatitis mice model using a methionine-choline (MCD) deficient diet. Steatosis and neutrophil infiltration, and apoptosis in liver tissue were significantly attenuated in KO mice compared with WT mice at 1 week after the administration of MCD diet. But these significant differences were transient. The time to peak level of the expression of PPAR γ was different between KO mice and WT mice. This may be one of the causes of the difference of pathophysiologic change between KO mice and WT mice.