Localization mechanism of a Ca^<2+> pump modulator, phospholamban in cardiac sarcoplasmic reticulum

磷蛋白（PLN）是心肌肌浆网（SR）心肌收缩性的调节因子。控制PLN的亚细胞定位为心力衰竭的新疗法带来了前景。本研究表明，PLN的c端区域对于PLN向sr的定位至关重要。基于这一发现，我们试图鉴定一种与PLN c端区域相互作用的假定蛋白。此外，还成功开发了一种新的靶向pln的适体，作为检测pln结合蛋白的有用分子工具。

Phospholamban (PLN) is a regulator of the myocardiac contractility in cardiac sarcoplasmic reticulum (SR). Controling the subcellular localization of PLN leads to the prospect for new therapy of heart failure. In this study, it was suggested that the C-terminal region of PLN is critical for localization of PLN to SR. Based on this finding, the identification of a putative protein interacting to the C-terminal region of PLN was attempted. Furthermore, a novel PLN-targeted aptamer was successfully developed as the useful molecular tool for detection of the PLN-binding protein.