Analysis of TCR regulation by a lysosomal protein LAPTM5

调节表面T细胞抗原受体（TCR）表达是调节免疫应答和预防T细胞过度活化和自身免疫的重要机制。抗原刺激后，TCR在溶酶体中内化并降解。然而，很少有参与这一过程的分子被确定。我们证明，溶酶体蛋白LAPTM 5负调节表面TCR的表达，促进其降解。这些结果鉴定了一种溶酶体蛋白，说明了控制表面TCR表达和T细胞活化的独特机制。

Modulation of surface T cell antigen receptor (TCR) expression is an important mechanism for the regulation of immune responses and the prevention of T cell hyperactivation and autoimmunity. After antigen stimulation, TCR are internalized and degraded in lysosomes. However, few of the molecules involved in this process have been identified. We demonstrate that the lysosomal protein LAPTM5 negatively regulated surface TCR expression by promoting its degradation. These results identify a lysosomal protein illustrate a unique mechanism for the control of surface TCR expression and T cell activation.