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Studies on Physiological Significance of Cytoskeleton Redistribution in the Mammalian Eggs and Its Signal Transduction Pathways

Studies on Physiological Significance of Cytoskeleton Redistribution in the Mammalian Eggs and Its Signal Transduction Pathways
哺乳动物卵细胞骨架重分配的生理意义及其信号转导途径研究
批准号:
21580340
负责人:
SUZUKI Hiroyuki
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
翻译
研究了哺乳动物卵母细胞成熟过程中细胞骨架的功能。结果表明,根据细胞周期的间期和M期,微丝和微管可能以不同的方式参与线粒体的再分布。动力蛋白,肌球蛋白和驱动蛋白,在卵母细胞成熟过程中的动力学也被阐明。中间丝蛋白角蛋白、波形蛋白和巢蛋白的分布也发生了变化。细胞周期调节因子cdc2的特异性抑制剂和MAP激酶激酶或Rho激酶抑制对细胞骨架结构的影响进行了评价。
英文摘要
Function of cytoskeleton in the mammalian oocytes during maturation was examined. Results revealed that microfilaments and microtubules may be differently involved in the mitochondrial redistribution according to the interphase and M-phase of the cell cycle. Dynamics of the motor proteins, myosin and kinesin, during oocyte maturation was also clarified. Furthermore, the distributional changes of intermediate filament proteins keratin, vimentin and nestin were shown. Effects of the specific inhibitors of the cell-cycle regulating factors cdc2 and MAP kinase kinase or Rho kinase inhibition on the cytoskeletal architecture were evaluated.
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DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [古山敬一, 椛嶋克哉, 松崎正敏, 鈴木裕之, 椛嶋克哉・山内浩一・松崎正敏・鈴木裕之]
通讯作者: 椛嶋克哉・山内浩一・松崎正敏・鈴木裕之
ハムスター卵成熟過程におけるミトコンドリアの再配置は,微小管ではなくアクチン繊維によって制御される
仓鼠卵母细胞成熟过程中的线粒体重排是由肌动蛋白纤维而不是微管控制的
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Kabashima, K., Matsuzaki, M., Suzuki, H., 椛嶋克哉,房家.,松崎正敏,鈴木裕之]
通讯作者: 椛嶋克哉,房家.,松崎正敏,鈴木裕之
Intermediate filament keratin dynamics during oocyte maturation requires MPF and MAP kinase activities in the hamster
卵母细胞成熟过程中的中间丝角蛋白动力学需要仓鼠中的 MPF 和 MAP 激酶活性
DOI: --
发表时间: 2010
期刊: Reprod. Dom. Anim
影响因子: --
作者: [Kabashima, K., Matsuzaki, M. and Suzuki, H.]
通讯作者: H.
Intermediate Filament Keratin Dynamics During Oocyte Maturation Requires Maturation/M-Phase Promoting Factor and Mitogen-Activated Protein Kinase Kinase Activities in the Hamster
卵母细胞成熟过程中的中间丝状角蛋白动力学需要仓鼠中的成熟/M相促进因子和丝裂原激活蛋白激酶激酶活性
DOI: --
发表时间: 2010
期刊: Reproduction in Domestic Animals
影响因子: 1.7
作者: [Kabashima, K., Matsuzaki, M., Suzuki, H.]
通讯作者: H.
共 12 条
    Role of THG-1 in squamous cell carcinoma development and its application to cancer therapy
    Development of therapy for craniosynostosis in Apert syndrome by FGF signal control
    • 批准号:
      24890063
    • 项目类别:
      Grant-in-Aid for Research Activity Start-up
    • 资助金额:
      $1.91万
    • 财政年份:
      2012
    • 负责人:
      SUZUKI Hiroyuki
    • 依托单位:
    Study on the Historical Process of Forming "Japanese Art History" Through the Comparison of Nineteenth-Century Japan, Europe, and the United States
    • 批准号:
      24520103
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.33万
    • 财政年份:
      2012
    • 负责人:
      SUZUKI Hiroyuki
    • 依托单位:
    Study on Fire Resistance Design of Steel Frames taking Deformation and Redundancy into account
    • 批准号:
      23360240
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $12.73万
    • 财政年份:
      2011
    • 负责人:
      SUZUKI Hiroyuki
    • 依托单位:
    海外基金