The transerelational research of the epoch-making in hard tissue regeneration with the rapidly proliferated iPS cells

日本的研究成果具有划时代意义，通过对小鼠源性成纤维细胞进行4种基因的重新编程，制造出了能够分化成多种细胞的诱导多能干细胞，而且在人类皮肤成纤维细胞中培育出了人类iPS细胞。然后，从患者的组织中收集细胞，取出到体外的细胞被诱导成多功能分化的iPS细胞，并再次分化为必需的细胞。利用系统工程技术在体外对细胞进行三维培养，实现无免疫排斥的“真细胞移植治疗”的早期成果，被认为是一种将细胞移植到组织中再生组织的医学治疗。然后，本研究将天然有机生物材料壳聚糖作为iPS细胞移植系统的支架，目标是在3-4年后实现临床应用。目的是培养和建立硬组织再生，特别是牙槽骨和牙本质。

Making an induced pluripotent stem cell by reprograming the mouse origined fibroblast with four kinds of gene was able to differentiate into varios cells became possible as an epoch-making result of the research in Japan, and, in addition, the establishment of human iPS cell was reported in the human skin fibroblast. Then, the cell is gathered from the patient' s organization now, the cell taken out to the outside of the body is induced to the iPS cell that has a versatile differentiation, and it differentiates into a necessary cell again. The achievement at the early stage of" True cell transplant treatment" without the immunity rejection that the cell is cultured by three dimensions by using the technology of the systems engineering in vitro, it is assumed to be a medical treatment of regenerating the tissue by transplantation of their cells to organization. Then, this research has used the chitosan that is the natural, organic biomaterials as scaffold of the iPS cell transplant system aiming at clinical practical application after 3-4 years. This aimed the development and the establishment of the hard tissue regeneration, especially alveolar bone and dentin.