Investigation of the inhibitory factors for osseointegration in the early stage of the implantation.

我们通过全基因组芯片分析全面评估了大鼠股骨内钛植入物周围基因组织的变化，并比较了获得性和非获得性骨整合大鼠模型中的基因表达。本研究提示在骨整合的建立过程中，基因的表达可能参与骨形成，但在一个复合体中表达的各种基因与骨整合的失败有关。

We comprehensively evaluated by whole genome microarray analysis for the variation of gene organization around titanium implants were implanted in the femur in rats, and we compared gene expression in a rat model of acquired and non-acquired osseointegration. This study suggested that the expression of genes may be involved in bone formation in the establishment of osseointegration, but that the various genes expressed in a complex were assosiated with failure of osseointegration.