Physiological and pathological analyses of cell adhesion molecules towards the development of diagnostic markers of human cancer

分析细胞黏附分子在肿瘤发生发展中的生理和病理作用，以建立新的人类肿瘤分子标志物。我们发现，细胞黏附分子CADM1的一个剪接变异体在小细胞肺癌(SCLC)中特异表达，为SCLC提供了一个候选的诊断标记。我们还发现CADM1可以与MET信号通路相互作用，可能在肺腺癌对EGFR-TKI治疗的获得性耐药中起作用。

Physiological and pathological roles of cell adhesion molecules in cancer development and progression were analyzed to establish novel molecular markers of human cancer. We found that a splicing variant of a cell adhesion molecule CADM1 was expressed exclusively in small cell lung cancer (SCLC), providing a candidate diagnostic marker of SCLC. We also found that CADM1 could cross-talk with the MET signaling and may play a role in acquired resistance of lung adenocarcinoma against EGFR-TKItreatment.