Biological function and gene regulation of epididymal-specific carboxylesterase (CES4)

用Ces4基因敲除小鼠研究了附睾特异性羧酸酯酶CES4的生物学功能。对附睾液的代谢组学分析表明，KO小鼠附睾液中的谷胱甘肽主要以氧化形式存在。氧化应激反应的血红素加氧酶-1(HO-1)在KO小鼠组织中的表达也增加。这些结果表明KO小鼠的附睾会暴露在氧化应激下。

The biological function of an epididymal-specific carboxylesterase, CES4, was studied using Ces4 knock out mouse. The metabolome analysis of epididymal cell extracts revealed that the most of the glutathione was identified as oxidative form in the epididymis of KO mouse. The expression of oxidative stress-responsive heme oxygenase-1 (HO-1) was also increased in the KO mouse tissue. These data indicated that the epididymis of KO mouse was exposed by oxidative stress.