Analysis of the histogenesis of thymoma

我们对胸腺瘤进行了免疫组化检查。A型胸腺瘤（14例）仅由pCK+/EMA-/VM）-/CDN-1+梭形上皮细胞组成。根本没有找到您的TCDM。化生性胸腺瘤（1例）由A型胸腺瘤的pCK+/VM-/EMA-/CDN-1+肿瘤细胞和pCK-/VM+/EMA+/CDN-1-成纤维细胞样化生上皮细胞（FMECs）两种不同成分镶嵌而成。在大多数AB型胸腺瘤（19例中的14例）中，A型样区由FMEC组成。5例胸腺瘤样区由A型胸腺瘤细胞组成。提示AB型胸腺瘤可分为化生型和常规型两种亚型。B型胸腺瘤中存在大量的TCDM和肿瘤细胞的β 5 t免疫反应性表明B型胸腺瘤基本上是c-TEC的肿瘤。我们还发现B3型胸腺瘤有两种亚型，即含有TCDM的分化亚型和不含TCDM的间变性亚型，尽管它们之间的临床关系尚不清楚。我们还发现，适当使用thy/TCDM、β 5 t、c-Kit和/或CD 5等标志物，可以区分B3型胸腺瘤和胸腺癌

We examined thymomas immunohitochemically. Type A thymoma (14 cases) were composed solely of pCK+/EMA-/VM)-/CDN-1+ shout spindle epithelial cells. Thy nor TCDM were not found at all. Metaplastic thymoma (1 case) was found to be mosaic of two different components, pCK+/VM-/EMA-/CDN-1+ tumor cells of type A thymoma and pCK-/VM+/EMA+/CDN-1- fibroblastoid metaplastic epithelial cells (FMECs). In the majority of type AB thymoma (14 of 19 cases), type A-like areas were composed of FMECs. In contrast, type A-like areas of remaining 5 cases were composed of type A thymoma cells. These findings indicate that there are two different subtypes in type AB thymoma, metaplastic type AB thymoma and conventional type AB thymoma. The presence of a considerable numbers of TCDM in types B thymomas and β5t-immunoreactivity of tumor cells indicates that type B thymomas are basically tumor of c-TECs. We also found that there are two subtypes of type B3 thymoma, the differentiated subtype containing TCDM and the anaplastic subutype lucking TCDM, although clinical between them remains unclear. We also found that type B3 thymoma are able to be distinguished from thymic carcinoma by proper use of markers such as thy/TCDM, β5t, c-Kit and/or CD5