Research of genetic factor for childhood-onset Type 1 diabetes

本研究分析了日本1型糖尿病患者的β-DRB1、DQB1、DPB1、A、C和B基因，以确定日本个体特有的候选基因。其中一些基因也与高加索人的糖尿病有关。TDT结果显示，日本患者中没有发现人类白细胞抗原基因的基因组印记。我们还在人类白细胞抗原以外的基因中发现了SNPs。

Most cases of type 1 diabetes mellitus are type 1A (T1A), caused by an autoimmune reaction, involving genetic and environmental factors, which ultimately disrupt insulin-producing pancreatic β cells.This study analyzed the HLA-DRB1, DQB1, DPB1, A, C, and B genes in Japanese patients with T1A to identify candidate genes specific for Japanese individuals. Some of the genes were also involved in diabetes in Caucasian. The results of TDT demonstrated no genomic imprinting of HLA genes in Japanese patients. We also identified SNPs in genes other than HLA.