Inhibition of Fibrosis and Inflammation by Triple Therapy with Pirfenidone, Edaravone, and Erythropoietin in Rabbits with Drug-Induced Lung Injury : Computed Tomography-Pathological Correlation

将药物性肺损伤兔分为对照组(G1)、吡非尼酮组(G2)和三联用药组(G3)(吡非尼酮、依达拉奉、促红细胞生成素)。28天时，G3的CT表现为面积较小，呈异常混浊，与G1相比有统计学意义(p=0。071)。在显微镜标本中，G1组和G3组的平均纤维化评分有显著差异(p&lt；0。05)。此外，G3组的平均纤维化评分往往小于G2组(p&lt；0。1)综上所述，单用吡非尼酮可抑制药物性肺损伤的进展，但三药合用可阻止进一步的进展。

We divided drug-induced lung injury rabbits into 3groups ; the control group(G1), pirfenidone group(G2), and a three-drug combination group(G3)(pirfenidone, edaravone, and erythropoietin). CT on day 28, G3 tended to exhibit a smaller area with abnormal opacity compared with G1(p=0. 071). In microscopic specimens, the average fibrosis score showed a significant difference between G1 and G3(p<0. 05). Moreover, the average fibrosis score tended to be smaller in G3 than in G2(p<0. 1).From the above, administration of pirfenidone alone suppressed the advancement of drug-induced lung injury, but the three-drug combination prevented further progression.