Development of Oxidative Cyclization Reactions via C-H CleavageBased on First Row Transition Metal Catalysts

我们专注于第一排过渡金属，特别是铜盐的潜力，并成功地开发了铜/O2体系独特的催化活性。也就是说，即使在常温下，铜催化的N-甲基苯胺和缺电子烯烃之间的氧化直接环化反应也是通过C-H裂解进行的。此外，当铜/氧催化剂用于杂芳烃与亚磺亚胺的反应时，通过C-H和C-N裂解生成直接的C-N键。

We have focused on the potential of first row transition metals, in particular, copper salts, and succeeded in the development of unique catalytic activity of copper/O2systems. Namely, the copper-catalyzed oxidative direct cyclization between N-methylanilines and electron-deficient olefins proceeded through C-H cleavage even under ambient conditions. In addition, when a similar copper/oxygen catalyst was applied to the reaction of heteroarenes with sulfoximines, the direct C-N bond formation occurred via both C-H and C-N cleavages.