Molecular basis for Epstein-Barr virus replication

EB病毒具有潜伏期和裂解期两个不同的生命周期，在潜伏期，BZLF 1启动子的再激活被抑制。我们确定启动子区域周围的组蛋白在诱导裂解性复制后甲基化为阴性，而阳性希斯顿标记物增加。JDP 2转录因子参与了潜伏感染的建立。在裂解阶段，病毒复制发生在复制区室（RC）中。BMRF-1核心存在于RC内。病毒DNA包装蛋白存在于核心中，病毒的早期和早期转录发生在核心外，而晚期转录发生在核心内。因此，每个事件由BMRF-1核心划分。

Epstein-Barr virus possesses two alternative life cycles, latent and lytic.In the latent phase, reactivation of BZLF1 promoter is inhibited. We determined that histons around the promoter region we re negatively methylated and positive histon markers were increased after induction of lytic replication. JDP2 transcription factor contributed the establishment of the latent infection. In the lytic phase, viral replication occurs in replication compartments(RC). BMRF-1 core exists within RC. Viral DNA packaging proteins were found in the core and viral immediate-eartly and early transcription occurs outside the core, while late transcription was inside. Thus, each events were compartmentalized by the BMRF-1 core.