Development of a new comprehensive treatment for dental caries based on minimum intervention dentistry

在日本，牙根表面龋齿等具有挑战性的牙齿疾病随着社会的快速老龄化而成为一个问题。我们试图在最小干预的基础上开发一种新的综合治疗龋病的方法。首先，我们开发了六氟硅酸铵（SiF）和抗菌药物对脱钙牙齿的再矿化和强化。其次，我们开发了用电磁波照射（EMWI）消毒龋相关细菌的方法。最后，我们研究了茶儿茶素对成纤维细胞的抗炎作用，以开发一种治疗深部龋齿病变的新方法。我们发现SiF处理羟基磷灰石的结晶度增加，抗菌药物如儿茶素对SiF有效。此外，我们还发现了EMWI对变形链球菌的杀菌或灭活作用。儿茶素抑制了牙髓成纤维细胞细胞因子和趋化因子的产生。这些结果表明了新的龋齿治疗的可能性。

In Japan, challenging cases of dental disease such as root surface caries become a problem in step with a rapid aging society. We tried to develop a new comprehensive treatment of caries based on minimum intervention. First, we developed the remineralization and reinforcement of decalcified tooth using ammonium hexafluorosilicate (SiF) with antimicrobial agents. Second, we developed the disinfection of caries related bacteria with electro-magnetic wave irradiation (EMWI). And finally, we examined the anti-inflammatory effects of tea catechin to fibroblasts to develop a new treatment for deep carious lesion.We found the increase of crystallinity of hydroxyapatite with SiF treatment and antibacterial agents such as catechin are effective with SiF. Also, we found the bacteriocidal or inactive effects of EMWI on S. mutans. Catechin had inhibited the production of cytokines and chemokines from pulpal fibroblasts.These results indicate the possibility of new caries treatment.