Electrolytes gradient dependent nutritional absorption.

多细胞生物体是由上皮细胞片包围的。上皮细胞片层是由上皮细胞通过细胞-细胞粘附复合物相互粘附而成。上皮细胞片层覆盖于人体内外，作为皮肤、肠道等器官发挥着生物学上的特殊作用，本研究分析了紧密连接机制，通过紧密连接机制，我们体内可以形成生物学上适宜的微环境。在这项研究中，我特别关注小肠使用clausdin-2和-15敲除小鼠。claudin-2和claudin-15基因敲除小鼠出现肠道电解质失衡，导致营养不良和婴儿死亡。

Multicellular organism is surrounded by the epithelial cell sheets. Epithelial cell sheet is composed of epithelial cells which are adhered each other by cell-cell adhesion complex. Epithelial cell sheets cover inside and outside of our body and the play a biological specific role as organ like skin, intestine and so on. In this research, I analyzed the tight junction mechanism, by which biologically adequate microenvironment can be formed in our body. In this study, I focused especially on small intestine using clausdin-2 and -15 knockout mice. The claudin-2 and -15 knockout mice showed imbalanced electrolytes of intestine induced malnutrition and infantile death.