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Probucol attenuates gentamicin-induced cochlear hair cell loss by inhibition of apoptosis.

Probucol attenuates gentamicin-induced cochlear hair cell loss by inhibition of apoptosis.
普罗布考通过抑制细胞凋亡来减轻庆大霉素诱导的耳蜗毛细胞损失。
批准号：
23592474
负责人：
SAKAMOTO Takashi
金额：
$3.49万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2011
资助国家：
日本
项目状态：
已结题
起止时间：
2011 至 2013
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592474/
关键词：
内耳有毛細胞抗脂血症薬アポトーシスプロブコール高脂血症薬高脂血症治療薬

项目摘要

项目成果

SAKAMOTO Takashi的其他基金

相关文献

中文摘要
翻译
普罗布考是具有抗炎和抗氧化作用的降脂药的代表之一，在治疗和预防心血管疾病方面有着悠久的临床应用历史。最近，一些研究揭示了它的神经保护作用。但迄今为止，普罗布考对耳蜗毛细胞的保护作用尚不明确。本实验采用人工耳蜗外植体培养24 h，普罗布考可减轻0.3 μ M庆大霉素诱导的毛细胞丢失和凋亡。普罗布考以100 μ M的剂量效果最好，说明有一个最佳的保护浓度。结果表明普罗布考对耳蜗毛细胞具有神经保护作用。
英文摘要
Probucol is one of the representative lipid-lowering agent with anti-inflammatory and antioxidant properties that has a long history of clinical application for the treatment and prevention of cardiovascular diseases. Recently, several studies have revealed its neuroprotective property. However, to date, protective effect of probucol for cochlear hair cell remains to be elucidated. In the present using cochlear explant culture for 24 h, probucol attenuated hair cell loss and apoptosis induced by 0.3 micro M of gentamicin. Moreover, 100 micro M of probucol was most effective, suggesting that there is an optimal concentration for protective effect. These results revealed the neuroprotective effect of probucol in cochlear hair cells.
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会议论文
Current concepts in age-related hearing loss: epidemiology and mechanistic pathways.
DOI： 10.1016/j.heares.2013.01.021
发表时间： 2013-09
期刊： Hearing research
影响因子： 2.8
作者： [Yamasoba T, Lin FR, Someya S, Kashio A, Sakamoto T, Kondo K]
通讯作者： Kondo K
Evaluation of the Internal Structure of Normal and Pathological Guinea Pig Cochleae Using Optical Coherence Tomography
DOI： 10.1159/000354620
发表时间： 2013-01-01
期刊： AUDIOLOGY AND NEURO-OTOLOGY
影响因子： 1.6
作者： [Kakigi, Akinobu, Takubo, Yuya, Yamasoba, Tatsuya]
通讯作者： Yamasoba, Tatsuya
Morphological and functional changes in a new animal model of Meniere's disease
DOI： 10.1038/labinvest.2013.91
发表时间： 2013-09-01
期刊： LABORATORY INVESTIGATION
影响因子： 5
作者： [Egami, Naoya, Kakigi, Akinobu, Yamasoba, Tatsuya]
通讯作者： Yamasoba, Tatsuya
Age-related hearing loss in Mn-SOD heterozygous knockout mice.
DOI： 10.1155/2013/325702
发表时间： 2013
期刊： Oxidative medicine and cellular longevity
影响因子： --
作者： [Kinoshita M, Sakamoto T, Kashio A, Shimizu T, Yamasoba T]
通讯作者： Yamasoba T
Research on the cosmotheism in european modern thought
  • 批准号：
    15K02424
  • 项目类别：
    Grant-in-Aid for Scientific Research (C)
  • 资助金额：
    $2.66万
  • 财政年份：
    2015
  • 负责人：
    SAKAMOTO Takashi
  • 依托单位：
    Rikkyo University
Research on the cosmotheism in european modern thought
Development of molecular probes for nucleic acids imaging based on 19F NMR/MRI
Development of genetic breeding technology for double disease resistant strains