Comprhensive examination for serum autoantigens in endogenous uveitis patients

本研究应用新的检测系统对内源性葡萄膜炎患者血清中的自身抗原进行了全面检测，将血清样本分为3组，发现Vogt-Koyanagi-Harada病患者血清中有10种蛋白质的含量比健康志愿者高1.5个水平以上。白塞病患者血清中有6种蛋白质水平较正常人升高一半，其中3种蛋白质水平升高与Vogt-Koyanagi-Harada病和白塞病相同。

In this study, serum autoantigens were examined comprhensively in the patients with endogenous uveitis by using our novel detection system.Serum samples were divided into 3 pooled groups.Among Vogt-Koyanagi-Harada disease patients, 10 kinds of proteins were elevated more than one-and-a-half levels compared with healthy volunteers in sera. Behcet's disease patients also showed that 6 kinds of serum proteins were increased levels by half compared with those of healthy subjects.We further demonstarted that 3 of these elevated proteins were common to Vogt-Koyanagi-Harada disease and Behcet disease.