Elucidation of salivary antioxidant protein for prevention of periodontitis-Analysis of antioxidant property and proteome-

本研究的目的是以唾液中活性氧的抗氧化性作为唾液的抗氧化性，研究唾液蛋白的抗氧化性，以及牙周病、唾液抗氧化性与白色念珠菌的抗菌活性之间的关系，为今后的预防医学研究提供依据。因此，唾液蛋白如组蛋白1、3、5和PrP1、2、3、4对羟基自由基具有抗氧化活性。结果表明，老年唐氏综合征(DS)患者唾液中抗氧化性增强，组织蛋白5含量升高。提示牙周炎、牙周炎、牙周炎和牙周炎患者的牙周炎、牙周炎等疾病的发生，可能是牙周炎、牙周炎等引起的。

The aim of the present study obtain the evidence, which is believed to have important implications for preventive medicine in the future, with physical activity as salivary antioxidant property of reactive oxygen species.We investigated the antioxidant property of salivary protein, and the relationship among periodontal disease, salivary antioxidant activity and salivary antimicrobial activity for Candida albicans. As a result, the salivary proteins such as histatin 1,3,5 and PRP1, 2, 3, 4 would have antioxidant activity against hydroxyl radical. It was shown that the enhancement of antioxidant property and increase of histatin 5 was observed in saliva of aged and Down syndrome (DS) patients. These results suggested that it would be likely that the adaptive response in the biological antibacterial and antioxidant system againtst the growth of Candida albicans and increased histatin 5 with the progression of periodontal disease may be occurred by periodontitis, aging and DS patients.