Development of atom-economical multicomponent coupling reactions via hypervalent ate complexes

我们已经开发了多组分偶联反应，其中来自芳基和中性亲核试剂的两性离子被炔基或全氟芳基溴捕获。这些反应通过形成由两性离子的芳基阴离子部分和有机溴化物的溴部分产生的高价络合物进行。异氰酸酯和环醚（THF，氧杂环丁烷）可以在反应中充当中性亲核试剂。此外，通过使用氧杂环丁烷衍生产物实现了生物活性分子的全合成。

We have developed multicomponent coupling reactions, where zwitterions derived from arynes and neutral nucleophiles are trapped by alkynyl or perfluoroaryl bromides. These reactions proceed through formation of hypervalent ate complexes generated from aryl anion moieties of the zwitterions and bromine moieties of the organic bromides. Isocyanides and cyclic ethers (THF, oxetane) can serve as neutral nucleophiles in the reaction. Furthermore, total synthesis of a biologically active molecule has been achieved by using the oxetane-derived product.