Association of co-stimulatory molecules with onset and recurrence of refractory uveoretinitis

ICOS、OX40、4-1BB在不同类型葡萄膜炎患者CD4 T细胞上的表达均显著高于健康人群。抗tnf α单抗治疗和全身皮质类固醇治疗前后，共刺激分子的表达量分别显著低于Behcet病、结节病和VKH病。用Con A刺激分离的CD4 T细胞和CD14细胞后，用抑制抗体检测活跃期和缓解期过表达的ICOS和OX40对T细胞增殖的影响。结果显示Th1和Th17细胞因子减少。

ICOS, OX40, and 4-1BB expression on CD4 T cells in various uveitiswas signigicant higher than that in healthy individuals. And, the expressin of costimulatory molecules was signigicantly lower than that in Behcet disease, sarcoidosis, and VKH disease before and after anti-TNFα mAb treatment and systemic corticosteroid therapy, respectively. After the isolated CD4 T cells and CD14 cells were stimulated with Con A, the effects of ICOS and OX40 that were overexpressed during active and remission phases on T cell proliferation was examined using inhibitory antibodies. The results showed that Th1 cytokines and Th17 cytokines were reduced.