Interaction between monocytes and bone marrow microenvironment in pathogenesis of multiple myeloma

在这项研究中，我们研究了单核细胞，骨髓微环境的一个组成部分，在MM进展中的作用。我们研究了MM细胞系单独培养或与骨髓间充质干细胞和/或MM患者单核细胞共培养的增殖情况。一致地，我们观察到MM细胞系在骨髓间充质干细胞或单核细胞的存在下，与仅细胞系对照相比，增殖增加。此外，骨髓间充质干细胞与单核细胞共培养诱导骨髓瘤细胞的增殖程度最大。除了增加增殖外，骨髓间充质干细胞和单核细胞还降低了骨髓瘤细胞的凋亡率。因此，我们的结果表明，单核细胞作为骨髓微环境的重要组成部分的作用突出。

In this study, we examined the role of monocyte, a component of bone marrow microenvironment, in the MM progression. We investigated the proliferation of MM cell lines cultured alone or co-cultured with BMSCs and/or monocytes of MM patients. Consistently, we observed increased proliferation of MM cell lines in the presence of either BMSCs or monocytes compared to cell line-only control. Furthermore, the co-culture of BMSCs plus monocytes induced the greatest degree of proliferation of myeloma cells. In addition to increased proliferation, BMSCs and monocytes decreased the rate of apoptosis of myeloma cells. Our results therefore suggest that highlights the role of monocyte as an important component of the bone marrow microenvironment.