Application of Super High-Purity Iron for Dental Treatment

作为一种修复材料，牙科金属提高了患者的生活质量。然而，需要更安全的替代材料，因为有几种口腔疾病可能是由牙科金属引起的。世界上无与伦比的下一代材料--超高纯铁(UHP-Fe)在东北大学材料研究所产生。我们还开发了一种利用实验动物模型评价生物材料的新型安全性测试方法。在本研究中，我们的目的是通过体内安全性测试来检验UHP-Fe在临床应用中是否具有更安全的生物材料价值。我们将UHP-Fe金属丝注射到小鼠皮下，5天后取周围组织包埋在金属丝中。为了研究金属离子在体内的洗脱情况，我们溶解了周围组织，并用质谱分析金属离子定量分析技术(电感耦合等离子体质谱-质谱仪)对溶液进行了分析。此外，还用扫描电子显微镜(SEM)检测了断丝后金属表面的腐蚀情况。超高纯铁表面几乎无腐蚀，皮下组织未见炎症反应。因此，超高纯铁是一种安全的生物材料，预示着它将成为未来一种新型的医用生物材料。

Dental metal has increased the patient's QOL as a repair material. However, safer alternative materials are desired, because there is a possibility that several oral disease may be caused by dental metal. The "ultra-high purity iron (UHP-Fe)" that is the next-generation material unparalleled in the world has been generated in the Institute for Materials Research at Tohoku University. We also developed the novel safety test for evaluating biomaterials using experimental animal model. In this study, our purpose is to examine whether UHP-Fe is valuable for safer biomaterials in the clinical application using the safety test in vivo. We injected the wire of UHP-Fe into the mice subcutaneously, Five days later we obtained the surrounding tissue embedded in the metal wire. To investigate the elution of metal ions in the in vivo, we were dissolved the surrounding tissue and the solution was analyzed by mass spectrum analysis metal ions quantitative analysis technique (ICP-MS method). In addition, the removed wires were detected the corrosion of metal surfaces by scanning electron microscopy (SEM method). There is almost no corrosion of the surface ultra-high purity iron and inflammation of the subcutaneous tissue was not observed. Therefore, ultra-high purity iron is a safe biological material, suggesting that it will become a new medical biomaterial in the future.