Evaluation of regions related to pain sensitization in the central nervous system for fibromyalgia patients using fMRI

6名纤维肌痛和7名严重肌筋膜疼痛患者和6名健康志愿者参加了这项研究。在治疗干预之前和之后进行全脑的功能性磁共振成像（fMRI）测量，即，插入口腔夹板装置。功能磁共振成像分析显示，部分患者的主要躯体感觉区、次级躯体感觉区、扣带回和中脑区的脑活动增加。

Six fibromyalgia and seven sever myofascial pain patients, and six healthy volunteers participated in this study. Measurement of functional magnetic resonance imaging (fMRI)for the whole brain was carried out before and after the therapeutic intervention, i.e., insertion of oral splint device. The analysis of fMRI data revealed that some patients exhibited the increased brain activities in primary somatosensory area, secondary somatosensory area, cingulate gyrus, and midbrain regions.