目標に向かう空間ナビゲーションのための視床下部ー海馬回路の機能解明

SuM终端的光遗传刺激没有损害社会行为，但我们发现，这些预测的抑制导致空间工作记忆和上下文新奇检测的深刻缺陷。结合光遗传学的T-迷宫行为期间的体内记录显示，这些输入的沉默以与行为变化相关的方式损害CA 1锥体细胞的轨迹特异性放电率调制。这些数据表明，SuM输入DG作为海马空间记忆的一种新的调制。我们目前正在进行分析，以了解这些表型如何与海马振荡和电路中动态信息路由的改变相关。

Optogenetic stimulation of SuM terminals did not impair social behavior, but we found that inhibition of these projections leads to profound deficits in spatial working memory and context novelty detection. In vivo recordings during T-maze behavior combined with optogenetics revealed that the silencing of these inputs impairs trajectory specific firing rate modulation of CA1 pyramidal cells in a manner that correlates with changes in behavior. These data establish that SuM input into the DG serves as a novel modulation of hippocampal spatial memory. We are currently conducting analyses to understand how these phenotypes relate to alterations in hippocampal oscillations and dynamic information routing in the circuit.