A cohort study on the_effect of shift work on the onset of circulatory diseases

目标;为了探讨轮班工作对循环系统疾病发病的影响，我们对某工厂的体力劳动者进行了队列研究。方法：1987年至1997年，我们对他们进行了跟踪调查。结果：10年间共发生脑血管事件18例，其中脑出血2例，脑梗死9例，蛛网膜下腔出血1例，心肌梗死5例。50-59岁夜班工人的累积发病率高于其他两组。然而，通过考克斯比例风险分析，调整年龄、平均血压和BMI后，夜班组循环系统疾病发作的风险比并不显著高。在1964例受试者中，高血压的发病率为87。高血压患病率为4.9%。在30岁以下人群中，“白班工人”的发病率为2.3%，“不上夜班的倒班工人”的发病率为3.4%，“上夜班的倒班工人”的发病率为6.5%。在30岁和40岁之间的工作时间表中，各组之间没有显着差异。根据Coxs比例风险模型，夜班工人与白班工人相比的风险比显著较高，为1.6。没有上夜班的轮班工人和白班工人一样正常。结论：夜班和倒班是高血压的危险因素。但未发现夜班、倒班与脑血管病、心肌梗死等循环系统疾病的关系。这一负面数据可能是由于该工厂的卫生管理，如高血压控制。

Objectives ; To investigate the effect of shift work on the onset of circulatory diseases, we took out a cohort study among the physical workers in a factory. The number of subjects was 2,702.Method ; We followed them from 1987 to 1997. The subjects were grouped into three groups by the type of work schedule in 1987, the baseline year, "day workers", "shift workers without midnight shift, and "shift workers with midnight shift".Results ; The onset number of vascular events during 10 years was 18 for all, 2 cerebral hemorrhage, 9 cerebral infarction, one subarachnoidal hemorrhage, arid 5 myocardial infarction. The cumulative incidence of "shift workers with midnight shift aged 50-59 years was higher than those of other two groups. However, the hazard ratio of the group with midnight shift for the onset of circulatory diseases adjusted for age, mean blood pressure, and BMI was not significantly high by the Cox's proportional hazard analysis. The onset, of hypertension was 87 from 1964 subjects. The incidence rate of hypertension was 4.9%. Among the subjects younger than 30 years old, the incidence rate was 2.3% in "day workers", 3.4% in "shift workers without midnight shift, and 6.5% in "shift workers with midnight shift". There was no significant difference between the groups by work schedule among thirties and forties. The hazard ratio of shift workers with midnight shift compared to day workers was significantly high, 1.6, by the Coxs proportional hazard model. That of shift workers without midnight shift was as sane as that of day workers. Conclusions ; It is suggested that night and shift work is a risk factor of hypertension. However we could not find the relationship between the night and shift work and circulatory diseases, such as cerebrovascular disease and myocardial infarction. This negative data might be caused from the health administration such as hypertension control in this factory.