Genetic diversity and adaptation among Southeast Asians

本研究的目的是了解人类的多样性，证明基于遗传多样性的遗传适应的存在。为此，我们研究了热带雨林居民身材矮小的分子基础和抗疟疾疾病的遗传特性。在研究过程中，我们从几个东南亚人群中收集了生物材料并建立了细胞系。田间研究：对于群体遗传研究，对Akha、Lisu和Mlaburi进行了血样采集。共收集标本350份，建立细胞系300株. Duffy血型的抗原是间日疟的受体，在这些人群中进行了血清学和分子筛选。鉴定出弱反应型标本，未发现Fy等位基因.至于SAO（东南亚卵细胞增多症）与疟疾种属的关系，不同种属对疟疾的抗性差异并不明显.在泰国南部通过病毒学调查了EB病毒（EBV）相关的T淋巴瘤;证实了外周血中存在EBV阳性T细胞。

The aims of this study are to find out human diversity, to prove the presence of the genetic adaptation based on the genetic diversity. For these, we have studied molecular bases for the short stature of tropical rain forest dwellers and genetic traits resistance to malarial diseases. During the study, we have collected biological materials and established cell lines from several Southeast Asian human populations.1. Field study: for the population genetic study, blood sampling was done for Akha; Lisu and Mlaburi. A total of 350 specimens were collected and 300 cell lines were established.2. Duffy blood group of which antigen is a receptor for vivax malaria was screened serologically and molecularly among these populations. Specimens of weakly reacted type were identified, whereas, Fy allele was not found.3. As for the relationships between SAO (Southeast Asian ovalocytosis) and malaria species, difference in the resistance to malaria by the species was not observed.4. Epstein-Barr virus (EBV) associated T-lyamphoma was surveyed by virologically in Southern Thailand ; the presence of EBV positive T-cells in the peripheral blood was confirmed.