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TR&D3: Experimental design in solid-state NMR spectroscopy

TR&D3: Experimental design in solid-state NMR spectroscopy
TR
批准号：
10194535
负责人：
ARTHUR G PALMER
金额：
$13.86万
依托单位：
NEW YORK STRUCTURAL BIOLOGY CENTER
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
项目状态：
已结题
起止时间：
2017-06-01 至 2022-06-30
来源：
https://reporter.nih.gov/project-details/10194535
关键词：
AnisotropyBiologicalBiopolymersCharacteristicsChemicalsComplexCryoelectron MicroscopyCrystallizationDataData AnalysesDetectionDevelopmentDiseaseElementsEquilibriumExperimental DesignsFree EnergyFreezingInvestigationJointsMagicMeasurementMedicineMembraneMethodologyMethodsMolecular ConformationMotionNMR SpectroscopyNatureNuclearPopulationProceduresProcessProteinsProtocols documentationRelaxationResearch PersonnelResolutionRoleSamplingSignal TransductionSignaling ProteinSiteSolubilitySolventsSpectrum AnalysisStructureSystemTechnologyTemperatureThermodynamicsTorsionX ray diffraction analysisbasecold temperaturecollegecomputer studiesconformational conversionexpectationexperimental studyhigh dimensionalityinsightinstrumentationmacromoleculemillisecondmimeticsrestraintsolid statesolid state nuclear magnetic resonancestudy population

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中文摘要
翻译
Tr&d3-固体核磁共振波谱的实验设计 摘要 高分辨率的基于MAS的SS核磁共振可以用来获得关于 生物聚合物的结构、热力学和动力学，并适用于广泛的 本机形式的系统不能被其他方法访问。溶液和固态核磁共振是 与X射线衍射和低温电子显微镜相辅相成，在以下方面 许多方法学方面和生物学机会方面。COMD/核磁共振的TRD3将 利用NYSBC的强大专业知识和仪器设备开发调查技术 固体核磁共振波谱研究生物大分子的构象动力学。
英文摘要
TR&D3 - Experimental design in solid-state NMR spectroscopy Summary High resolution MAS-based SSNMR can be used to obtain detailed site-specific information on the structure, thermodynamics and dynamics of biopolymers, and is applicable to a broad range of systems that in native form are inaccessible to other methods. Solution and solid-state NMR are complementary to each other, and to X-ray diffraction and cryo electron microscopy, in terms of many methodological aspects and in terms of biological opportunities. TR&D3 at CoMD/NMR will utilize the strong expertise and instrumentation at NYSBC to develop technology for investigation of conformational dynamics of biological macromolecules by solid-state NMR spectroscopy.
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Acquisition of an 800 MHz NMR Spectrometer Console and Probes
RM1 Center on Macromolecular Dynamics by NMR Spectroscopy at the New York Structural Biology Center (CoMD/NMR)
RM1 Center on Macromolecular Dynamics by NMR Spectroscopy at the New York Structural Biology Center (CoMD/NMR)
Acquisition of a 900 MHz NMR Spectrometer Console and Probes
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