Native Alzheimer's Disease Resource Center for Minority Aging Research (NAD-RCMAR)

总体摘要 美国印第安人/阿拉斯加原住民（AI/AN）和夏威夷原住民/太平洋岛民（NHPIs）越来越多地 关注阿尔茨海默病和相关痴呆症（ADRD），因为这些疾病将有一个主要的 对他们社区的影响。虽然人工智能/人工神经网络和NHPI在文化上是多样化的，而且分散在世界各地， 在美国，他们都有很高的ADRD风险因素患病率。此外，AI/AN和NHPI的预期寿命 在过去的50年里，人口增长了30年， 65岁及以上感知需求、高风险和有限数据的汇合促使我们提出一个 少数族裔老龄化研究中的本土阿尔茨海默病相关资源中心（NAD-RCMAR）。我们的研究 团队提供独特的科学资源和机会，以及广泛的学术和 社区伙伴关系。总部设在华盛顿州立大学（WSU），与合作者在斯坦福大学 和科罗拉多大学，我们将创建一个创新的计划，以了解，干预，并减轻 AI/AN和NHPI经历的ADRD相关健康差异。该中心的主题将强调 AI/AN和NHPI从个人到群体水平的健康差异和老龄化。我们的研究教育 组件将资助由被称为RCMAR科学家的早期职业调查人员领导的有价值的试点研究。 RCMAR科学家将接受方法，测量和研究设计方面的指导和培训， 高科学标准和文化上的适当性。他们还将接受指导， 成功的资助提案，使他们能够追求ADRD研究的独立职业生涯。特别是，13 AI/AN或NHPI专业人员将作为合作研究者、顾问或RCMAR参与 科学家我们的具体目标是：1）建立基础设施，汇集资源，并提供科学专业知识 通过指导有前途的初级和中级研究人员， 代表性不足的少数民族科学家在ADRD研究中的持续职业生涯，重点是AI/AN和NHPI 2）招募RCMAR科学家，特别是AI/AN，NHPI和其他URM背景的科学家， 在ADRD的社会、行为、流行病学和临床科学方面进行试点研究，并利用这些研究成果， 试点研究作为提供导师和职业指导的工具;以及3）促进ADRD的进步 研究并增加独立的代表性不足的少数民族研究人员的数量，重点是 AI/AN和NHPI卫生教师，他们可以解决AI/AN和NHPI老年人的健康和福祉，健康 从个人到社会层面的差异和老龄化。NAD-RCMAR还将利用国家 由Buchwald博士和曼森博士创建的卫星中心网络，由AI/AN研究人员领导。这些卫星 中心将确保我们的努力是全国范围内，特别是我们的招聘RCMAR科学家，我们的 识别AI/AN和NHPI中与ADRD相关的数据集，以及我们对结果的传播。这项工作将 帮助解决NIA在代表性不足的少数民族中的ADRD研究优先事项，如2012年所述 国家计划解决阿尔茨海默病。我们的中心响应NIA的兴趣，在多样化的科学 劳动力

OVERALL ABSTRACT American Indians/Alaska Natives (AI/ANs) and Native Hawaiians/Pacific Islanders (NHPIs) are increasingly concerned about Alzheimer’s disease and related dementias (ADRD), as these conditions will have a major impact on their communities. Although AI/ANs and NHPIs are culturally diverse and dispersed throughout the US, they share a high prevalence of ADRD risk factors. In addition, life expectancies for AI/ANs and NHPIs have improved over the last 50 years by as much as 30 years, resulting in a tripling of their population share of people aged 65 and older. The confluence of perceived need, high risk, and limited data motivates us to propose a Native Alzheimer’s Disease-related Resource Center in Minority Aging Research (NAD-RCMAR). Our research team offers unique scientific resources and opportunities as well as an extensive network of academic and community partnerships. Based at Washington State University (WSU), with collaborators at Stanford University and the University of Colorado, we will create an innovative program to understand, intervene on, and mitigate the ADRD-related health disparities experienced by AI/ANs and NHPIs. The Center’s theme will emphasize AI/AN and NHPI health disparities and aging from the individual to the population level. Our Research Education Component will fund meritorious Pilot Studies led by early-career investigators known as RCMAR Scientists. RCMAR Scientists will receive mentorship and training in methods, measurements, and study designs that meet high scientific standards and are culturally appropriate. They also will be mentored in the development of successful funding proposals so that they can pursue independent careers in ADRD research. Notably, 13 professionals who are either AI/AN or NHPI will participate as Co-Investigators, Consultants, or RCMAR Scientists. Our Specific Aims are to: 1) Build infrastructure, assemble resources, and provide scientific expertise to enhance the diversity of the aging research workforce by mentoring promising junior and mid-level underrepresented minority scientists for sustained careers in ADRD research, focusing on AI/AN and NHPI populations; 2) Recruit RCMAR Scientists, especially those of AI/AN, NHPI, and other URM backgrounds, to conduct Pilot Studies in the social, behavioral, epidemiological, and clinical sciences on ADRD, and use these Pilot Studies as a vehicle for delivering mentorship and career guidance; and 3)Promote advances in ADRD research and increase the number of independent underrepresented minority researchers, with an emphasis on AI/AN and NHPI health faculty, who can address the health and well-being of AI/AN and NHPI elders, health disparities, and aging from the individual to the societal level. NAD-RCMAR will also capitalize on the national network of Satellite Centers created by Drs. Buchwald and Manson and led by AI/AN researchers. These Satellite Centers will ensure that our efforts are national in scope, especially our recruitment of RCMAR Scientists, our identification of datasets relevant to ADRD in AI/ANs and NHPIs, and our dissemination of results. This work will help address NIA’s research priorities for ADRD among underrepresented minorities, as articulated in the 2012 National Plan to Address Alzheimer's Disease. Our Center responds to NIA’s interest in diversifying the scientific workforce.