VGM: Vanderbilt Genomic Medicine Training Program

项目摘要 本申请旨在更新范德比尔特的范德比尔特基因组医学（VGM）培训计划 大学医学中心（VUMC）。VGM研究员接受数据科学，生物信息学，实验室 科学和基因组发现;该计划还指导研究员进行基因组医学实践。VGM 建立在VUMC内部关键使能资源和基础设施方面长达数十年的优势之上，包括：1） BioVU是将DNA样本与电子病历（EMR）连接起来的最大生物银行， 机构（现在> 244，000名受试者），2）参与三个NHGRI资助的网络：电子医疗 记录和基因组学（eMERGE）网络和eMERGE协调中心， 实践（IGNITE）网络和未诊断疾病网络（UDN），3）药物基因组学 加强护理和治疗决策的资源（PREDICT）项目， 电子健康记录（EHR）中的药物基因组学测试，以指导药物和剂量选择4）a 精准肿瘤学计划，应用肿瘤基因组测序来识别癌症中可操作的突变 和个性化的靶向治疗，以及6）全国最大的生物医学信息学系， 在临床信息技术方面有强大的研究、教育和支持计划。该计划有35 高度合作和资金充足的教师导师谁团队提供基础和临床研究 博士的机会-水平和医学博士-级博士后研究员。受训人员将参加轮调、研讨会， 期刊俱乐部，务虚会，并与其他临床和研究人员和教师互动。在范德比尔特的 生物医学研究教育和培训（BRET）办公室，该计划将提供负责任的行为， 研究（RCR）培训，高标准的个人发展计划（IDP）和职业发展 该计划的目标是培养研究员成为基因组医学的下一代领导者。科学 咨询委员会和外部咨询委员会为VGM计划提供宝贵建议 发展和增强。该计划积极寻求来自不同人群的候选人， 专业和研究背景。我们的基本模式是加强多学科培训 通过根据以往经验为每个受训者量身定制的课程，再加上配对指导， 提供临床和方法学专业知识。

PROJECT SUMMARY This application seeks to renew the Vanderbilt Genomic Medicine (VGM) training program at Vanderbilt University Medical Center (VUMC). VGM fellows are trained in data science, bioinformatics, laboratory science, and genomic discovery; the program also instructs fellows on the practice of genomic medicine. VGM builds on decades-long strengths in critical enabling resources and infrastructure within VUMC including: 1) BioVU, the largest biobank linking DNA samples to electronic medical records (EMRs) at a single academic institution (now >244,000 subjects), 2) Participation in three NHGRI-funded networks: the Electronic Medical Records and Genomics (eMERGE) network and eMERGE coordinating center, the Implementing Genomics in Practice (IGNITE) Network, and the Undiagnosed Disease Network (UDN), 3) The Pharmacogenomic Resource for Enhanced Decisions In Care and Treatment (PREDICT) project which embeds pharmacogenomic testing within electronic health records (EHRs) to guide drug and dosage choices 4) a Precision Oncology program that applies tumor genome sequencing to identify actionable mutations in cancers and to personalized target therapy, and 6) the largest Department of Biomedical Informatics in the country, with strong research, education, and support programs in clinical information technology. The program has 35 highly collaborative and well-funded faculty preceptors who team up to provide both basic and clinical research opportunities to Ph.D.-level and M.D.-level postdoctoral fellows. Trainees will participate in rotations, seminars, journal clubs, and retreats and interact with other clinical and research fellows and faculty. Under Vanderbilt’s Biomedical Research Education and Training (BRET) Office, the program will provide Responsible Conduct in Research (RCR) training, high-standard Individual Development Plans (IDP), and Career Development programs with the goal of developing fellows to be next-generation leaders in genomic medicine. A Scientific Advisory Committee and an External Advisory Committee provide valuable advice on VGM program development and enhancement. The program actively seeks candidates from diverse populations and professional and research backgrounds. Our fundamental model is to enhance multidisciplinary training through a curriculum tailored for each trainee based on prior experience, coupled to paired mentoring to provide both clinical and methodological expertise.