University of Florida Older Americans Independence Center (OAIC)

项目摘要 佛罗里达大学老年美国人独立中心（OAIC）的使命有两个方面：1）优化 通过跨学科方法，促进提高老年人的身体机能和行动能力， 独立性;和2）在老龄化和残疾研究方面培训早期研究人员，同时发展他们的 领导才能我们的目标是提高晚年的健康和独立性，特别注重流动性。 为了完成我们的使命，我们的战略是吸引来自不同行为， 临床、基础和技术科学学科，共同研究重点是“促进流动性” 和独立。”贯穿整个生物医学研究领域，包括分子生物学， 动物研究、临床研究、行为科学、流行病学、数据科学、人工智能，以及 工程，我们的研究工作解决了OAIC的总体目标：增加科学知识， 更好地保持或恢复老年人的独立性。我们的研究目标是：1）评估， 利用老年科学和转化研究，生物，共病，心理社会，环境， 行为、认知和其他因素导致认知和身体功能下降，丧失活动能力， 以及2）在临床和临床前研究中开发并可靠地测试干预措施， 目标活动性，以预防，延迟或恢复与年龄相关的身体和认知功能下降。我们 教育目标是培养未来的老龄化临床转化研究的领导者。满足这些 目标拟议的OAIC培训研究教育核心（REC）学者和支持研究人员， 资源，服务，外部研究，发展项目和试验/探索性研究，通过七个 集成核心： ·领导和行政核心（LAC）; ·研究教育核心（REC）; 试点/探索性研究核心（PESC）; ·临床研究核心（RC 1）; 代谢与转化科学核心（RC 2）; ·生物统计学核心（RC 3）;以及 数据科学与应用技术核心（Data Science and Applied Technology Core，RC 4） 在这次更新OAIC应用程序中，我们将增加丰富的专业知识和卓越的跟踪记录， 当前融资周期的成功。我们的审计和调查办公室的一个相关优势是， 跨学科的核心，项目和研究人员谁解决一个共同的研究重点跨越整个 生物医学研究的范围。

Project Summary The mission of the University of Florida Older Americans Independence Center (OAIC) is twofold: 1) to optimize older persons’ physical performance and mobility through interdisciplinary approaches to promote independence; and 2) to train early stage investigators in aging and disability research while developing their leadership qualities. Our goal is to enhance late-life health and independence, with a special focus on mobility. To accomplish our mission, our strategy is to attract studies and inventive investigators from diverse behavioral, clinical, basic, and technological science disciplines with a common research focus on “promotion of mobility and independence.” Traversing the entire spectrum of biomedical investigation, including molecular biology, animal studies, clinical research, behavioral sciences, epidemiology, data science, artificial intelligence, and engineering, our research effort addresses the OAIC’s general goal: to increase scientific knowledge that leads to better ways to maintain or restore independence of older people. Our research objectives are to: 1) assess, using geroscience and translational research, the biological, co-morbid, psychosocial, environmental, behavioral, cognitive, and other factors that contribute to cognitive and physical function decline, loss of mobility, and loss of independence; and 2) develop and reliably test, in clinical and preclinical studies, interventions that target mobility to prevent, delay, or recover the age-related declines in physical and cognitive function. Our educational objective is to train future leaders in clinical translational research on aging. To meet these objectives the proposed OAIC trains Research Education Core (REC) Scholars and supports investigators, resources, services, external studies, development projects, and pilot/exploratory studies through seven integrated cores: • Leadership and Administrative Core (LAC); • Research Education Core (REC); • Pilot/Exploratory Studies Core (PESC); • Clinical Research Core (RC1); • Metabolism and Translational Science Core (RC2); • Biostatistics Core (RC3); and • Data Science and Applied Technology Core (RC4). In this renewal OAIC application we will augment the wealth of expertise and remarkable track record of success of the current funding cycle. A relevant strength of our OAIC is the concerted action of the interdisciplinary cores, projects, and investigators who address one common research focus spanning the entire spectrum of biomedical investigation.