Developmental Research Program

项目总结/摘要 案例GI癌症孢子发育研究计划（DRP）的总体目标是开发 创新和多样化的方法，专注于整个范围内的GI癌症转化研究， 通过预防、筛查、诊断、治疗和生存来确定病因。SPORE DRP将 提供1）财政支持，2）核心设施服务和3）知识监督和指导试点 研究项目和调查人员。重点将放在支持新的调查人员以及 用新方法治疗胃肠道癌症的研究者。对于个人基本或 临床研究者，DRP领导小组将确定补充翻译研究者， 作为顾问将制定特别计划，以刺激结肠直肠以外新领域的胃肠道癌症研究 癌案例GI SPORE认为试点项目机制是启动的重要机会 高风险/高影响的研究，并将相应地为这些建议提供适当的优先次序。与 来自CWRU医学院，克利夫兰诊所Taussig癌症中心，案例的支持 综合癌症中心和孢子基金，DRP将支持至少3个，并在某些年份4试点 每个项目每年5万美元。试点项目的征集将由多个机构宣布， 电子通知系统，通过与系主任和系主任直接沟通，并邀请 有着令人兴奋的新方法的特定科学家。试点提案将使用NIH 9分评分进行评估 系统由SPORE DRP评估小组组成的一系列选定的教职员工参与 在GI癌症研究和NIH和其他国家组织同行评审研究中拥有丰富的经验 路段

PROJECT SUMMARY/ABSTRACT The overall objective of the Case GI Cancer SPORE Developmental Research Program (DRP) is to develop innovative and diverse approaches to focus on GI Cancer translational research across the spectrum from etiology through prevention, screening, diagnostics, therapeutics, and survivorship. The SPORE DRP will provide 1) financial support, 2) Core Facility Services and 3) intellectual oversight and mentoring for pilot research projects and investigators. Emphasis will be placed on supporting new investigators as well as established investigators with new approaches to GI cancers. For meritorious proposals from individual basic or clinical investigators, the DRP leadership group will identify complementary translational investigators to serve as advisors. Special plans will be instituted to stimulate GI cancer research in new areas other than colorectal cancer. The Case GI SPORE considers the pilot project mechanism to be an important opportunity for initiation of high risk/high impact research and will accordingly provide appropriate prioritization for such proposals. With support from the CWRU School of Medicine, The Cleveland Clinic Taussig Cancer Center, The Case Comprehensive Cancer Center and SPORE Funds, the DRP will support at least 3, and in some years 4 pilot projects per year at $50,000 each. Solicitation for pilot projects will be announced by multiple, institution wide, electronic notice systems, by direct communication with department heads and deans, and by invitations to specific scientists with exciting new approaches. Pilot proposals will be evaluated using the NIH 9 point scoring system by the SPORE DRP Evaluation Panel composed of selected series of faculty members with involvement in GI Cancer Research and extensive experience in NIH and other national organization peer review study sections.