Core C: Human Tissue Validation

项目总结（核心C：人体组织确认） 人体组织验证核心将为CWOW提供重要的研究支持。神经变性疾病 近年来，随着重大进展，病理学和遗传学变得越来越令人兴奋和复杂， 是由人体死后组织的工作所产生的在本申请中，莱亚T.格林伯格将领导 人体组织确认核心（核心C）。人类核心的目标是（1）直接支持这一CWOW的 来自tau蛋白病患者和对照组的经过充分表征和仔细处理的人体组织的项目;（2） 验证项目1和2在人体标本和类人猿中的相关性结果;（3）开发 增强的工具，用于提高每个单一生物标本样本检索的信息量。

PROJECT SUMMARY (CORE C: HUMAN TISSUE VALIDATION) The Human Tissue Validation Core will provide vital research support to the CWOW. Neurodegenerative disease pathology and genetics have become increasingly exciting and complex in recent years, with major advances arising from work accomplished using human postmortem tissue. In this application, Dr. Lea T. Grinberg will lead the Human Tissue Validation Core (Core C). The Human Core goals are to (1) directly supporting this CWOW’s Projects with well-characterized and carefully treated human tissue from tauopathy patients and controls; (2) validating the relevance results from Projects 1 and 2 in human specimens and assembloids; (3) developing enhanced tools for boosting the amount of information retrieved for each single biospecimen samples.