PRIDE Summer Institute in Cardiovascular Disease Comorbidities, Genetics and Epidemiology (CVD-CGE)

项目摘要。 华盛顿大学针对RFA-HL-19-002提出的PRIDE申请建议在我们的 目前成功的暑期研究所（SI）计划，并根据我们的经验， 以及从我们的SIPID/PRIDE项目中吸取的经验教训。我们增强计划的首要目标是 提供创造性和高度相关的教育活动，主要侧重于研究经验， 加强生物医学研究队伍多样性的辅导活动。我们将实现这一目标 通过招募传统上在生物医学研究队伍中代表性不足的初级教师， 包括：A）来自种族/族裔群体的个人在全国健康相关的 科学; B）身体残疾的个人; C）来自弱势背景的个人;以及（D） 妇女我们的WU SIPID/PRIDE计划（9个队列，47名学员超过12年）一直非常 成功：我们的学员在进入WU SIPID/PRIDE之前没有收到任何NIH“R”赠款 计划，但在该计划之后，他们收到了9个“R”赠款，包括7个R 01（所有赠款的总数 在培训期间/之后增加73%）。SIPID/PRIDE期间/之后的出版物总数 784篇同行评议文章，与计划实施前相比，增长了443%。通过 下面列出的拟议活动，我们的学员将接受培训，以制定独立的研究计划， 与心脏、肺、血液和睡眠（HLBS）疾病相关的领域。根据目前的反馈， 前学员，教师和导师，我们提出了一个显着增强骄傲计划。亮点 WU PRIDE更新申请包括：A）高度相关CVD合并症的新焦点， 流行病学说教讲座。目前对遗传流行病学和生物信息学的深入关注将 继续在网上提供教育材料（电子学习）; B）继续并进一步强调 有效的指导和学员的研究项目的日常头脑风暴; C）强烈的写作技能 发展，特别注重撰写科学手稿; D）发展竞争性赠款 申请新的“小型研究项目（SRP）”计划; E）招募前4名中的8名学员 年（从3年增加）; F）2周长的第1次和第2次SI（从3周减少）; G）全年 指导，包括在贝塞斯达举行的为期3天的年中会议和为期3天的年度会议; H）为期2周的第二次 社会团体，社会团体之间有3天的重叠时间，以促进联网和同行指导; 每个SI队列记录HLBS疾病相关领域的进展，资助和手稿撰写， 学术进步（不变）。初级教师，过渡博士后研究员和科学家， 残疾人谁是在他们的职业生涯的早期阶段，并宣布在HLBS疾病的研究重点， 被招募。该计划的有效性将通过学员成功地确保独立 赠款支持、科学出版物和学术推广。

Project Summary. PRIDE application from Washington University in response to RFA-HL-19-002 proposes to build upon our current successful Summer Institute (SI) program and to significantly enhance it based on our experiences with and lessons learned from our SIPID/PRIDE programs. The overarching goal of our enhanced program is to provide creative and highly relevant educational activities with primary focus on research experiences and mentoring activities for enhancing diversity of the biomedical research workforce. We will accomplish this goal by recruiting junior faculty who are traditionally underrepresented in the biomedical research workforce, including: A) individuals from racial/ethnic groups shown to be nationally underrepresented in health-related sciences; B) individuals with physical disabilities; C) individuals from disadvantaged backgrounds; and (D) Women. Our WU SIPID/PRIDE programs (9 cohorts, 47 mentees over 12 years) have been extremely successful: our mentees had not received any NIH “R” grants before they entered the WU SIPID/PRIDE program, but after the program they received 9 “R” grants including 7 R01's (total number of all grants increased by 73% during/after training). The total number of publications during/after SIPID/PRIDE has been 784 peer-reviewed articles, an impressive 443% increase compared to before the program. Through the proposed activities listed below, our mentees will be trained to develop independent research programs in areas relevant to Heart, Lung, Blood, and Sleep (HLBS) disorders. Based on feedback from current and former trainees, faculty and mentors, we propose a significantly enhanced PRIDE program. Highlights of the WU PRIDE renewal application include: A) a new focus on highly-relevant CVD comorbidities and epidemiology didactic lectures. Current in-depth focus on Genetic Epidemiology and Bioinformatics will continue, with educational material available on web (e-learning); B) continued and increased emphasis on effective mentoring and daily brainstorming of mentees' research projects; C) intense writing skills development, with particular focus on writing scientific manuscripts; D) development of competitive grant applications for the NEW “Small Research Project (SRP)” program; E) recruiting 8 Mentees each of the first 4 years (increased from 3 years); F) 2-week long 1st and 2nd SI (decreased from 3 weeks); G) year-long mentoring that includes a 3-day mid-year meeting and 3-day annual meeting in Bethesda; H) 2-week long 2nd SI, with 3-day overlap between SI groups to facilitate networking and peer-mentoring; I) 2-year follow-up of each SI cohort to document progress in areas relevant to HLBS disorders, grant and manuscript writing and academic advancement (unchanged). Junior faculty, transitioning post-doctoral fellows and scientists with disabilities who are in early stages of their careers and with a declared research focus in HLBS disorders will be recruited. Effectiveness of the program will be assessed by mentees' success in securing independent grant support, scientific publications and academic promotions.