A novel platform for the biosynthesis of commercially valuable saxitoxins
A novel platform for the biosynthesis of commercially valuable saxitoxins
批准号:
LP200100537
负责人:
Prof Brett Neilan
金额:
$29.17万
依托单位国家:
澳大利亚
项目类别:
Linkage Projects
财政年份:
2021
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2021-04-01 至 2024-12-31
中文摘要
蛤蚌毒素是一种强效的微生物毒素,对食品和水质构成重大威胁。高纯度的石蜡毒素是环境监测和细胞生理学研究所必需的。某些类似物也显示出作为长效和非成瘾性止痛药的前景。然而,从自然资源中获取这些化合物是复杂和不可持续的。该项目旨在利用最新的合成生物学技术来表征、修饰和表达蛤蚌毒素的生物合成途径,从而为工业和研究提供有价值的毒素类似物的可持续来源。这种新颖的“绿色技术”将有利于环境、人类健康和澳大利亚的经济。
英文摘要
Saxitoxins are potent microbial toxins, which pose a significant threat to food and water quality. Highly pure saxitoxins are required for environmental monitoring and studies of cell physiology. Certain analogues have also shown promise as long-lasting and non-addictive pain blockers. However, the procurement of these compounds from natural sources is convoluted and unsustainable. This project aims to use the latest synthetic biology techniques to characterise, modify and express saxitoxin biosynthesis pathways, thereby providing a sustainable source of toxin analogues of value to industry and research. This novel 'green technology' will benefit the environment, human health and the Australian economy.
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